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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanostructured electrospun nonwovens of poly(epsilon-caprolactone)/quaternized chitosan for potential biomedical applications

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Author(s):
dos Santos, Danilo Martins [1] ; Leite, Ilaiali Souza [2] ; Bukzem, Andrea de Lacerda [1] ; de Oliveira Santos, Rachel Passos [1] ; Frollini, Elisabete [1] ; Inada, Natalia Mayumi [2] ; Campana-Filho, Sergio Paulo [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Chem, Av Trabalhador Sao Carlense, BR-40013566 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Carbohydrate Polymers; v. 186, p. 110-121, APR 15 2018.
Web of Science Citations: 8
Abstract

Blend solutions of poly(epsilon-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples were used, namely QCh1 ((DQ) over bar = 47.3%; (DPv) over bar = 2218) and QCh2 ((DQ) over bar = 71.1%; (DPv) over bar = 1427). According to the characteristics of QCh derivative and to the QCh content on the resulting PCL/QCh nonwoven, the nanofibers displayed different average diameter (175 nm-415 nm), and the nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity (175%-425%) and water vapor transmission rate (1600 gm(-2) 24 h-2500 gm(-2) 24 h). The surface hydrophilicity of nonwovens increases with increasing QCh content, favoring fibroblast (HDFn) adhesion and spreading. Tensile tests revealed that the nonwovens present a good balance between elasticity and strength under both dry and hydrated state. Results indicate that the PCL/QCh electrospun nonwovens are new nanofibers-based biomaterials potentially useful as wound dressings. (AU)

FAPESP's process: 10/02526-1 - Studies on the effects of the high intensity ultrasound irradiation on the aqueous suspensions of chitin and chitosan
Grantee:Sérgio Paulo Campana Filho
Support Opportunities: Regular Research Grants