Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Depletion study, withdrawal period calculation and bioaccumulation of sulfamethazine in tilapia (Oreochromis niloticus) treated with medicated feed

Full text
Author(s):
Nunes, Katia S. D. [1] ; Vallim, Jose H. [2] ; Assalin, Marcia R. [2] ; Queiroz, Sonia C. N. [2] ; Paraiba, Lourival C. [2] ; Jonsson, Claudio M. [2] ; Reyes, Felix G. R. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Dept Food Sci, Sch Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
[2] Embrapa Meio Ambiente, Rodovia SP 340 Km 127-5, BR-13820000 Jaguariuna, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Chemosphere; v. 197, p. 89-95, APR 2018.
Web of Science Citations: 2
Abstract

The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422 mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively. Both methods were validated based on international and Brazilian guidelines and shown to be suitable for the intended purposes. The withdrawal period to reach the maximum residue level (MRL) of 100 mu g/kg, according to the European Union (EU) legislative framework to all substances belonging to the sulfonamide (SA) group (EU, 2010), was 10 days (260 C-day). After treatment, the maximum level of SMZ accumulation in the tilapia muscle was 1.6 mg/kg. SMZ was shown to be quickly excreted by tilapia. Thus, considering the acceptable daily intake of SMZ established by the Codex Commission (0-0.05 mg/kg bw), and a factor of 5 times the upper amount of fish consumption in Brazil (38 kg/year), this study showed that there is a low risk of adverse effects to consumers. This study offers subsidies not only for the establishment of public policies with regard to the use of veterinary drugs currently not allowed in a country by their legal legislative framework for fish farming, but also to fish producers for the proper handling to ensure safe fish fillets. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
Grantee:Felix Guillermo Reyes Reyes
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE