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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats

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Author(s):
Soriano, Renato N. [1, 2] ; Braga, Sara P. [3] ; Breder, Jessica S. C. [1] ; Batalhao, Marcelo E. [1] ; Oliveira-Pelegrin, Gabriela R. [4] ; Ferreira, Luiz Fernando R. [5, 6] ; Rocha, Maria Jose A. [4] ; Carnio, Evelin C. [1] ; Branco, Luiz G. S. [4]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Nursing Sch Ribeirao Preto, Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Fed Juiz de Fora, Div Physiol & Biophys, Dept Basic Life Sci, BR-35010177 Governador Valadares, MG - Brazil
[3] Univ Fed Juiz de Fora, Phys Therapy, Governador Valadares, MG - Brazil
[4] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil
[5] Univ Tiradentes, Aracaju, SE - Brazil
[6] Inst Technol & Res, Aracaju, SE - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Experimental Physiology; v. 103, n. 3, p. 397-407, MAR 1 2018.
Web of Science Citations: 5
Abstract

In recent years, hydrogen sulfide (H2S) has been reported as a gaseous modulator acting in several tissues in health and disease. In animal models of systemic inflammation, the plasma H2S concentration increases in response to endotoxin (bacterial lipopolysaccharide, LPS). The most striking response in the acute phase reaction of systemic inflammation is fever, but we found no reports of the peripheral action of H2S on this thermoregulatory response. We aimed at investigating whether endogenous systemic H2S modulates LPS-induced fever. A temperature datalogger capsule was inserted in the abdominal cavity of male Wistar rats (220-270g) to record body core temperature. These animals received an i.p. injection of a systemic H2S inhibitor (propargylglycine; 50 or 75mg kg(-1)), immediately followed by an i.p. injection of LPS (50 or 2500g kg(-1)), and were exposed to different ambient temperatures (16, 22 or 27 degrees C). At 22 degrees C, but not at 27 degrees C, propargylglycine at 75mg kg(-1) significantly attenuated (P<0.0001) the fever induced by LPS (50g kg(-1)), indicating a modulatory (permissive) action of endogenous peripheral H2S on brown adipose tissue (BAT) thermogenesis. Evidence on the modulatory role of peripheral H2S in BAT thermogenesis was strengthened when we discarded (i) the possible influence of the gas on febrigenic signalling (when measuring plasma cytokines), and (ii) its interaction with the nitric oxide pathway, and mainly when (iii) we carried out physiological and pharmacological activations of BAT. Endogenous peripheral H2S modulates (permits) BAT activity not only in fever but also during maintenance of thermal homeostasis in cold environments. (AU)

FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
Grantee:Luiz Guilherme de Siqueira Branco
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/01417-0 - Participation of hydrogen sulfide (H2S) on rostral ventrolateral medulla in the modulation of ventilatory responses to hypoxia
Grantee:Alberto Ferreira Donatti
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/24950-3 - Role of Hydrogen Sulphide (H2S) on the ventilatory responses to hypercapnia
Grantee:Luiz Guilherme de Siqueira Branco
Support Opportunities: Regular Research Grants