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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Resistance Training on Matrix Metalloproteinase Activity in Skeletal Muscles and Circulation During Aging

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Author(s):
de Sousa Neto, Ivo V. [1] ; Durigan, Joao L. Q. [1] ; Guzzoni, Vinicius [2] ; Tibana, Ramires A. [3] ; Prestes, Jonato [4] ; Selistre de Araujo, Heloisa S. [2] ; Marqueti, Rita de Cassia [1]
Total Authors: 7
Affiliation:
[1] Univ Brasilia, Grad Program Sci & Technol Hlth, Brasilia, DF - Brazil
[2] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil
[3] Univ Fed Mato Grosso, Grad Program Phys Educ, Cuiaba - Brazil
[4] Univ Catolica Brasilia, Grad Program Phys Educ, Brasilia, DF - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 9, MAR 12 2018.
Web of Science Citations: 1
Abstract

Aging is a complex, multifactorial process characterized by the accumulation of deleterious effects, including biochemical adaptations of the extracellular matrix (ECM). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) onmetalloproteinase 2 (MMP-2) activity in skeletalmuscles and, MMP-2 and MMP-9 activity in the blood circulation of young and old rats. Twenty-eight Wistar rats were randomly divided into four groups (n = 7 per group): young sedentary (YS); young trained (YT), old sedentary (OS), and old trained (OT). The stair climbing RT consisted of one training session every 2 other day, with 8-12 dynamic movements per climb. The animals were euthanized 48 h after the end of the experimental period. MMP-2 and MMP-9 activity was measured by zymography. There was higher active MMP-2 activity in the lateral gastrocnemius and flexor digitorum profundus muscles in the OT group when compared to the OS, YS, and YT groups (p <= 0.001). Moreover, there was higher active MMP-2 activity in the medial gastrocnemius muscle in the OT group when compared to the YS and YT groups (p <= 0.001). The YS group presented lower active MMP-2 activity in the soleus muscle than the YT, OS, OT groups (p <= 0.001). With respect to active MMP-2/9 activity in the bloodstream, the OT group displayed significantly reduced activity (p <= 0.001) when compared to YS and YT groups. In conclusion, RT up-regulates MMP-2 activity in aging muscles, while down-regulating MMP-2 and MMP-9 in the blood circulation, suggesting that it may be a useful tool for the maintenance of ECM remodeling. (AU)

FAPESP's process: 11/11229-3 - Aging-related alterations in extracellular matrix and its adaptations to strength training in calcaneal tendon of rats: molecular, cellular, and biomechanical approach
Grantee:Heloisa Sobreiro Selistre de Araújo
Support Opportunities: Regular Research Grants
FAPESP's process: 10/19390-5 - Aging-related alterations in extracellular matrix and its adaptations to strength training in Calcaneal tendon of rats: molecular, cellular, and biomechanical approach.
Grantee:Rita de Cássia Marqueti Durigan
Support Opportunities: Scholarships in Brazil - Post-Doctoral