Inflammatory and Metabolic Responses to Different Resistance Training on Chronic Obstructive Pulmonary Disease: A Randomized Control Trial

Author(s)

de Alencar Silva, Bruna S. ^[1] ; Lira, Fabio S. ^[2] ; Rossi, Fabricio E. ^[3] ; Ramos, Dionei ^[4] ; Uzeloto, Juliana S. ^[4] ; Freire, Ana P. C. F. ^[4] ; de Lima, Fabiano F. ^[4] ; Gobbo, Luis A. ^[1] ; Ramos, Ercy M. C. ^[4]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Phys Educ, Skeletal Muscle Assessment Lab, Presidente Prudente - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, Presidente Prudente - Brazil

^[3] Univ Fed Piaui, Dept Phys Educ, Immunometab Skeletal Muscle & Exercise Res Grp, Teresina - Brazil

^[4] Sao Paulo State Univ UNESP, Dept Phys Therapy, Presidente Prudente - Brazil

• Document type: Journal article
• Source: FRONTIERS IN PHYSIOLOGY; v. 9, MAR 23 2018.
• Web of Science Citations: 5

Abstract

Background: Low-grade inflammation can be present in chronic obstructive pulmonary disease (COPD), which may affect the regulation of muscle protein and body metabolism. Regular exercise show improvement in muscle strength and dyspnea in patients with COPD, however, the response to training on inflammatory and metabolic disorders is unclear. In this study, we compared the effects of resistance training using weight machines and elastic resistance (bands and tubes) on the inflammatory and metabolic responses in patients with COPD. Methods: Patients with COPD were randomized into three groups: elastic band group (EBG), elastic tube group (ETG), and weight machines equipment group (MG). EBG and ETG were analyzed together {[}elastic group (EG)]. The participants were evaluated for pulmonary function (spirometry), peripheral muscle strength (digital dynamometry), IL-6, TNF-alpha, IL-10, IL-15 (Immunoassay), glucose, triacylglycerol, total cholesterol, HDL-c, and albumin levels (Enzymatic colorimetric). Blood samples were collected to assess the acute and chronic exercise responses after 12 weeks of training protocol. Results: The patient's mean age was 71.53 +/- 6.97 years old. FEV1 (percent predicted) was 50.69 +/- 16.67 and 45.40 +/- 15.15% for EG and MG, respectively (p = 0.28). All groups increased muscle strength (p < 0.05) with no differences between groups. The acute response to exercise after 12 weeks of training showed improvement of inflammation when compared to baseline. Regarding the chronic effects, it was observed a decrease of all cytokines, except IL-10 (p < 0.05). After 12 weeks of training, the analysis of the metabolic profile presented a reduction in glucose concentration (p < 0.01), with no differences between groups (p = 0.30) and a decrease in triacylglycerol for the EG (p > 0.01). Conclusions: Training with elastic resistances or conventional weight machines showed improvement of inflammation response after 12 weeks of training. Chronically, both training groups showed anti-inflammatory effects, with the EG showing a strong tendency to improve IL-10/TNF-alpha ratio and IL-10 levels. (AU)

• FAPESP's process: 15/13353-4 - Clinical practice guidelines in physiotherapy for the management of chronic respiratory diseases: a critical appraisal
• Grantee: Juliana Souza Uzeloto
• Support type: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 17/10145-7 - Effects of the inclusion of a functional circuit to aerobic and resistance training on functionality, physical activity in daily life and immuno-metabolic response of patients with COPD: a randomized clinical trial with follow-up
• Grantee: Ercy Mara Cipulo Ramos
• Support type: Regular Research Grants