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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

Full text
Author(s):
Piccoli, Julia [1] ; Hein, Robert [2] ; El-Sagheer, Afaf H. [2, 3] ; Brown, Tom [2] ; Cilli, Eduardo M. [1] ; Bueno, Paulo R. [1] ; Davis, Jason J. [2]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP - Brazil
[2] Univ Oxford, Dept Chem, South Parks Rd, Oxford OX1 3QZ - England
[3] Suez Univ, Fac Petr & Min Engn, Chem Branch, Dept Sci & Math, Suez 43721 - Egypt
Total Affiliations: 3
Document type: Journal article
Source: Analytical Chemistry; v. 90, n. 5, p. 3005-3008, MAR 6 2018.
Web of Science Citations: 13
Abstract

Electrochemical immunosensors offer much in the potential translation of a lab based sensing capability to a useful ``real world{''} platform. In previous work we have introduced an impedance-derived electrochemical capacitance spectroscopic analysis as supportive of a reagentless means of reporting on analyte target capture at suitably prepared mixed-component redox-active, antibody-modified interfaces. Herein we directly integrate receptive aptamers into a redox charging peptide support in enabling a label-free low picomolar analytical assay for C-reactive protein with a sensitivity that significantly exceeds that attainable with an analogous antibody interface. (AU)

FAPESP's process: 12/22820-7 - The sensitive label free detection of disease markers using electrochemical immittance
Grantee:Eduardo Maffud Cilli
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/02343-8 - Controlled release of peptides from latex biomembranes and development of capacitive biosensors containing self-assembled peptide
Grantee:Eduardo Maffud Cilli
Support type: Regular Research Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC