Sleep findings in Brazilian children with congenital Zika syndrome

Author(s)

Pinato, Luciana ^[1] ; Ribeiro, Erlane M. ^{[2, 3]} ; Leite, Rebeka F. P. ^[2] ; Lopes, Thayse F. ^[2] ; Pessoa, Andre L. S. ^{[2, 4]} ; Guissoni Campos, Leila M. ^[5] ; Piffer, Giovanna E. ^[5] ; Souza, Ana L. D. M. ^[1] ; Giacheti, Celia M. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Marilia, SP - Brazil

^[2] Albert Sabin Childrens Hosp, Fortaleza, Ceara - Brazil

^[3] Christus Univ Ctr, Fortaleza, Ceara - Brazil

^[4] State Univ Ceara UECE, Fortaleza, Ceara - Brazil

^[5] Univ Marilia UNIMAR, Marilia, SP - Brazil

• Document type: Journal article
• Source: Sleep; v. 41, n. 3 MAR 2018.
• Web of Science Citations: 5

Abstract

Study Objectives: Zika virus infection during pregnancy may result in congenital Zika syndrome (CZS), whose characteristics are being described. Methods: The aim of the present study was to investigate the sleep characteristics of 136 infants and toddlers (88 with CZS and 48 with typical development {[}TD], age and gender matched, 60% girls and 40% boys in both groups) using the Brief Infant Sleep Questionnaire. The ages of children in both groups ranged from 5 to 24 months (CZS 15.9 +/- 0.4 vs. TD 15.8 +/- 1.0 months, p = 0.90). Results: The results show that 34.1% of CZS and 2% of TD children were defined as poor sleepers, 15% of CZS and 2% of TD children remained awake at night for a period longer than 1 hr, and 24% of CZS and 2% of TD children slept less than 9 hr. The CZS group showed shorter total sleep time (CZS 11.24 +/- 2.6 vs. TD 12.02 +/- 1.9 hr, p = 0.03) and shorter nocturnal sleep duration than the TD group (CZS 8.2 +/- 0.2 vs. TD 9.4 +/- 0.2 hr, p = 0.0002). In contrast to the control group (p = 0.02, r = -0.34), in the CZS group, no correlation was found between age and nocturnal wakefulness. Future studies should explore these data in relation to the development and maturation of the central nervous system of these children. Conclusions: Considering the well-known consequences of poor sleep quality on health in several populations, the presence of sleep disorders should be considered in CZS using multidisciplinary treatments. (AU)

• FAPESP's process: 11/51495-4 - Induction of melatonin synthesis by glia and neurons in injured central nervous system
• Grantee: Luciana Pinato
• Support Opportunities: Research Grants - Young Investigators Grants