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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A nano-magnetic electrochemical sensor for the determination of mood disorder related substances

Full text
Author(s):
Cincotto, Fernando H. [1] ; Carvalho, Daniel A. S. [1] ; Canevari, Thiago C. [2] ; Toma, Henrique E. [3] ; Fatibello-Filho, Orlando [1] ; Moraes, Fernando C. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil
[2] Univ Prebiteriana Mackenzie, Sch Engn, BR-01302907 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: RSC ADVANCES; v. 8, n. 25, p. 14040-14047, 2018.
Web of Science Citations: 3
Abstract

The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe3O4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L-1, respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples. (AU)

FAPESP's process: 16/12519-9 - Development of multifunctional hybrid nano matrix: use as intelligent systems for drug delivery and substrates for construction of (bio) electrochemical sensors
Grantee:Thiago da Cruz Canevari
Support Opportunities: Regular Research Grants
FAPESP's process: 16/12926-3 - Removal and real time determination of environmental pollutants using electrochemical photoassisted system
Grantee:Fernando Cruz de Moraes
Support Opportunities: Regular Research Grants
FAPESP's process: 16/16565-5 - Development of ultra-sensitive methods for RNA detection for the diagnosis of Head and Neck Cancer
Grantee:Fernando Henrique Cincotto
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/24725-4 - Supramolecular chemistry and nanotechnology
Grantee:Henrique Eisi Toma
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/13312-5 - Development and application of carbon and nanoparticles base electrodes for the determination of species of interest in different matrices
Grantee:Orlando Fatibello Filho
Support Opportunities: Regular Research Grants