Typical and atypical neurotransmitters in neuropsychiatric disorders
| Full text | |
| Author(s): |
Cincotto, Fernando H.
[1]
;
Carvalho, Daniel A. S.
[1]
;
Canevari, Thiago C.
[2]
;
Toma, Henrique E.
[3]
;
Fatibello-Filho, Orlando
[1]
;
Moraes, Fernando C.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil
[2] Univ Prebiteriana Mackenzie, Sch Engn, BR-01302907 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | RSC ADVANCES; v. 8, n. 25, p. 14040-14047, 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe3O4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L-1, respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples. (AU) | |
| FAPESP's process: | 16/12926-3 - Removal and real time determination of environmental pollutants using electrochemical photoassisted system |
| Grantee: | Fernando Cruz de Moraes |
| Support type: | Regular Research Grants |
| FAPESP's process: | 11/13312-5 - Development and application of carbon and nanoparticles base electrodes for the determination of species of interest in different matrices |
| Grantee: | Orlando Fatibello Filho |
| Support type: | Regular Research Grants |
| FAPESP's process: | 16/12519-9 - Development of multifunctional hybrid nano matrix: use as intelligent systems for drug delivery and substrates for construction of (bio) electrochemical sensors |
| Grantee: | Thiago da Cruz Canevari |
| Support type: | Regular Research Grants |
| FAPESP's process: | 13/24725-4 - Supramolecular chemistry and nanotechnology |
| Grantee: | Henrique Eisi Toma |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/16565-5 - Development of ultra-sensitive methods for RNA detection for the diagnosis of Head and Neck Cancer |
| Grantee: | Fernando Henrique Cincotto |
| Support type: | Scholarships in Brazil - Post-Doctorate |