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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications

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Picco, Agustin S. [1] ; Ferreira, Larissa F. [1, 2] ; Liberato, Michelle S. [1] ; Mondo, Gabriela B. [1, 3] ; Cardoso, Mateus B. [1, 2, 3]
Total Authors: 5
[1] CNPEM, LNLS, Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[2] Univ Fed ABC, Programa Posgrad Biotecnociencia, BR-09210580 Santo Andre - Brazil
[3] Univ Estadualde Campinas GBM1, IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Nanomedicine; v. 13, n. 2, p. 179-190, JAN 2018.
Web of Science Citations: 4

Aim: To study freeze-drying of silica nanoparticles (SiO(2)NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. Methods: SiO(2)NPs were synthesized using a Stober-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO(2)NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants. Results: Glucose was found to be the most suitable protectant against the detrimental effects of lyophilization. The minimum concentration of carbohydrate required to effectively protect SiO(2)NPs from aggregation during freeze-drying is influenced by the nanoparticle's size and texture. Negligible aggregation was observed during storage. Conclusion: Carbohydrates can be used during SiO(2)NPs freeze-drying process to obtain redispersable solids that maintain original sizes without residual aggregation. (AU)

FAPESP's process: 14/21910-8 - Evolution of silica nanoparticles in biological media: a study on protein corona formation, aggregation and cellular uptake
Grantee:Agustín Silvio Picco
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/02145-7 - Study of the interaction between proteins and functionalized silica nanoparticles
Grantee:Larissa Fernanda Ferreira
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/16905-0 - Correlation between the protein corona and biological activity of silica nanoparticles
Grantee:Gabriela Borba Mondo
Support type: Scholarships in Brazil - Doctorate (Direct)