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Functionalization of composite nanoparticles for biomedical applications


The project described here aims to functionalize the surface of two distinct types of composites: silica-antitumor drug and silver-silica composites. The aim is to improve performance and biomedical compatibility of these structures. The silica-antitumor drug composites will be functionalized with folate seeking to obtain a target specific structure, thus it is expected that this will be preferentially endocytosed by tumor cells. Nanoparticles will be characterized in every step of functionalization and delivery tests will be done by using tumoral and normal cells. Silver-silica core-shell nanoparticles will be functionalized with beta-lactam antibiotics. Thus, the composite formed possibly will present dual bactericidal activity arising from the synergy between silver and beta-lactam agent. The composites will be characterized in each step of the synthesis process and inhibition tests with resistant and non-resistant bacteria will be performed. In both systems (silica-antitumor drug and silver-silica), it is intended to initially cover the nanoparticles with 3-aminopropiltrietoxissilano (APTES), obtaining amino groups on the surface of the nanoparticle. Thereafter, the amino groups will react with the carboxyl groups of the molecule of interest, via coupling reaction, so that they will be linked to the nanoparticle.Moreover, through this proposal is expected to consolidate the young complex materials research group at LNLS. The subject of the proposed research will develop areas of synthesis, functionalization, characterization and applications of functionalized complex systems dedicated to nanomedicine. This is of extreme importance for the country taking into account the shortage of researchers working on the proposed theme in the national territory. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS, CARLOS S. B.; HANCHUK, TALITA D. M.; WENDER, HEBERTON; SHIGEYOSI, WILLIAN T.; KOBARG, JORG; ROSSI, ANDRE L.; TANAKA, MARCELO N.; CARDOSO, MATEUS B.; GARCIA, FLAVIO. Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy. SCIENTIFIC REPORTS, v. 7, . (11/17402-9, 11/21954-7, 15/25406-5, 11/18647-5)
MORENO, YOLICE P.; CARDOSO, MATEUS B.; MONCADA, EDWIN A.; DOS SANTOS, JOAO H. Z.. Correlating the Morphological Properties and Structural Organization of Monodisperse Spherical Silica Nanoparticles Grown on a Commercial Silica Surface. ChemPhysChem, v. 16, n. 14, p. 2981-2994, . (11/21954-7)
DE BARROS, HELOISE RIBEIRO; CARDOSO, MATEUS BORBA; DE OLIVEIRA, CAROLINA CAMARGO; CAVICHIOLO FRANCO, CELIA REGINA; BELAN, DANIEL DE LIMA; VIDOTTI, MARCIO; RIEGEL-VIDOTTI, IZABEL C.. Stability of gum arabic-gold nanoparticles in physiological simulated pHs and their selective effect on cell lines. RSC ADVANCES, v. 6, n. 12, p. 9411-9420, . (11/21954-7, 14/22322-2)
LIVI, SEBASTIEN; SILVA, ADRIANA A.; PEREIRA, JESSICA; NGUYEN, THI KHANH LY; SOARES, BLUMA GUENTHER; CARDOSO, MATEUS BORBA; GERARD, JEAN-FRANCOIS; DUCHET-RUMEAU, JANNICK. Supercritical CO2-organosilane mixtures for modification of silica: Applications to epoxy prepolymer matrix. CHEMICAL ENGINEERING JOURNAL, v. 241, p. 103-111, . (11/21954-7)
AFFONSO DE OLIVEIRA, JESSICA FERNANDA; CARDOSO, MATEUS BORBA. Partial Aggregation of Silver Nanoparticles Induced by Capping and Reducing Agents Competition. Langmuir, v. 30, n. 17, p. 4879-4886, . (11/21954-7, 11/15937-2)
DE OLIVEIRA, LUCIANE FRANCA; GONCALVES, JULIANNA DE OLIVEIRA; GONCALVES, KALIANDRA DE ALMEIDA; KOBARG, JOERG; CARDOSO, MATEUS BORBA. Sweeter But Deadlier: Decoupling Size, Charge and Capping Effects in Carbohydrate Coated Bactericidal Silver Nanoparticles. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 9, n. 11, p. 1817-1826, . (11/21954-7)
CAPELETTI, LARISSA BRENTANO; DE OLIVEIRA, LUCIANE FRANCA; GONCALVES, KALIANDRA DE ALMEIDA; AFFONSO DE OIVEIRA, JESSICA FERNANDA; SAITO, ANGELA; KOBARG, JOERG; ZIMNOCH DOS SANTOS, JOAO HENRIQUE; CARDOSO, MATEUS BORBA. Tailored Silica-Antibiotic Nanoparticles: Overcoming Bacterial Resistance with Low Cytotoxicity. Langmuir, v. 30, n. 25, p. 7456-7464, . (11/21954-7)
DE SOUZA E SILVA, JULIANA MARTINS; PASTORELLO, MURILO; KOBARG, JOERG; CARDOSO, MATEUS BORBA; MAZALI, ITALO ODONE. Selective Synthesis of Silver Nanoparticles onto Potassium Hexaniobate: Structural Organisation with Bactericidal Properties. ChemPhysChem, v. 14, n. 18, p. 4075-4083, . (11/21954-7)
BARALDI DIAS, CARLOS SATO; GARCIA, FLAVIO; MAZALI, ITALO ODONE; CARDOSO, MATEUS BORBA; DE SOUZA E SILVA, JULIANA MARTINS. Direct route for preparing multi-oxide inorganic nanocomposites of nanoparticles-decorated nanotubes. Journal of Alloys and Compounds, v. 774, p. 1133-1139, . (11/17402-9, 11/21954-7, 11/18647-5)
MELO FERREIRA, DANIELLE CRISTHINA; GIORDANO, GABRIELA FURLAN; DOS SANTOS PENTEADO SOARES, CAIO CESAR; AFONSO DE OLIVEIRA, JESSICA FERNANDA; MENDES, RENATA KELLY; PIAZZETTA, MARIA HELENA; GOBBI, ANGELO LUIZ; CARDOSO, MATEUS BORBA. Optical paper-based sensor for ascorbic acid quantification using silver nanoparticles. Talanta, v. 141, p. 188-194, . (11/21954-7, 13/22429-9)
CORNELSEN, PATRICIA A.; QUINTANILHA, RONALDO C.; VIDOTTI, MARCIO; GORIN, PHILIP A. J.; SIMAS-TOSIN, FERNANDA F.; RIEGEL-VIDOTTI, IZABEL C.. Native and structurally modified gum arabic: Exploring the effect of the gum's microstructure in obtaining electroactive nanoparticles. Carbohydrate Polymers, v. 119, p. 35-43, . (11/21954-7)

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