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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibacterial properties of chitosan-based coatings are affected by spacer-length and molecular weight

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Author(s):
Vaz, Juliana M. [1] ; Taketa, Thiago B. [1] ; Hernandez-Montelongo, Jacobo [2, 3] ; Chevallier, Pascale ; Cotta, Monica A. [2] ; Mantovani, Diego [4, 5] ; Beppu, Marisa M. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Fac Engn Quim, Dept Engn Mat & Bioproc DEMBio, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Dept Fis Aplicada, Campinas, SP - Brazil
[3] Univ Catolica Temuco, Fac Ingn, Dept Ciencias Matemat & Fis, Temuco, La Araucania - Chile
[4] Laval Univ, Dept Min Met & Mat Engn, Lab Biomat & Bioengn, Quebec City, PQ - Canada
[5] Laval Univ, CHU Quebec Res Ctr, Quebec City, PQ - Canada
Total Affiliations: 5
Document type: Journal article
Source: Applied Surface Science; v. 445, p. 478-487, JUL 1 2018.
Web of Science Citations: 7
Abstract

Chitosan is a biopolymer with antibacterial properties, which are dependent on its molecular weight (Mw) and its degree of deacetylation (DDA). When grafted on surfaces as a coating, chitosan antibacterial efficiency is also dependent on the polymer chain conformation on the surface, as the amine groups, responsible of the antibacterial effect, should be available for contact with bacteria. To investigate this behavior, chitosans with different Mw were grafted onto plasma aminated surfaces through three different spacers: glutaric anhydride (GA), poly(ethylene-glycol) bis(carboxymethyl) ether (PEGb), and poly (ethylene-alt-maleic anhydride) (PA). The grafting efficiency was evaluated by X-ray Photoelectron Spectroscopy (XPS), contact angle and Rose Bengal test, while morphological features were assessed by profilometry analyses. Results evidenced a clear influence of the anchor arm length and of the Mw of chitosan both on the grafting efficiency and on the antibacterial behavior. PA CHIMW surface exhibited a better antibacterial response compared to GA and PEGb, which could be correlated to a denser coating coverage as seen by XPS and profilometry results. Further, PA CHIMW coating displayed a higher amine density, thus promoting the interaction with the bacteria cell wall. Based on these results, chitosan-based coatings can then be extended to a wide range of antibacterial applications. (C) 2018 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/14888-3 - Adhesion behavior of Pseudomonas aeruginosa and Staphylococcus aureus bacteria on nanostructured films based on chitosan: studies at the micro and nanoscales.
Grantee:Jesús Jacobo Hernández Montelongo
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 10/51748-7 - Chemical and structural analysis of Xylella fastidiosa biofilms
Grantee:Mônica Alonso Cotta
Support Opportunities: Regular Research Grants
FAPESP's process: 13/10957-0 - Xylella fastidiosa-vector-host plant interaction and approaches for citrus variegated chlorosis and citrus canker control
Grantee:Alessandra Alves de Souza
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/05135-1 - Nanostructured antimicrobial coatings containing chitosan produced by self-assembly technique (layer-by-layer) for textile substrates
Grantee:Thiago Bezerra Taketa
Support Opportunities: Scholarships in Brazil - Doctorate