Individual Test Point Fluctuations of Macular Sensitivity in Healthy Eyes and Eyes With Age-Related Macular Degeneration Measured With Microperimetry

Author(s)

Salgueiro Barboni, Mirella Telles ^{[1, 2]} ; Szepessy, Zsuzsanna ^{[2, 3]} ; Ventura, Dora Fix ^[1] ; Nemeth, Janos ^{[2, 3]}

Affiliation

^[1] Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, Sao Paulo - Brazil

^[2] Semmelweis Univ, Dept Ophthalmol, Maria U 39, H-1085 Budapest - Hungary

^[3] Bion Innovat Ctr, Budapest - Hungary

• Document type: Journal article
• Source: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY; v. 7, n. 2 MAR 2018.
• Web of Science Citations: 2

Abstract

Purpose: To establish fluctuation limits, it was considered that not only overall macular sensitivity but also fluctuations of individual test points in the macula might have clinical value. Methods: Three repeated measuremets of microperimetry were performed using the Standard Expert test of Macular Integrity Assessment (MAIA) in healthy subjects (N = 12, age = 23.8 +/- 1.5 years old) and in patients with age-related macular degeneration (AMD) (N = 11, age = 68.5 +/- 7.4 years old). A total of 37 macular points arranged in four concentric rings and in four quadrants were analyzed individually and in groups. Results: The data show low fluctuation of macular sensitivity of individual test points in healthy subjects (average = 1.38 +/- 0.28 dB) and AMD patients (average = 2.12 +/- 0.60 dB). Lower sensitivity points are more related to higher fluctuation than to the distance from the central point. Fixation stability showed no effect on the sensitivity fluctuation. The 95th percentile of the standard deviations of healthy subjects was, on average, 2.7 dB, ranging from 1.2 to 4 dB, depending on the point tested. Conclusion: Point analysis and regional analysis might be considered prior to evaluating macular sensitivity fluctuation in order to distinguish between normal variation and a clinical change. (AU)

• FAPESP's process: 16/04538-3 - Dystrophin and the human visual system: study of the visual phenotypes of Duchenne muscular dystrophy patients
• Grantee: Dora Selma Fix Ventura
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/22007-5 - Optimization of the visual functional ability in patients with macular diseases using visual training programs
• Grantee: Mirella Telles Salgueiro Barboni
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 14/26818-2 - Development and implementation of visual evaluation methods: clinical applications and animal models
• Grantee: Dora Selma Fix Ventura
• Support Opportunities: Research Projects - Thematic Grants