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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Grey and white matter volumes either in treatment-naive or hormone-treated transgender women: a voxel-based morphometry study

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Spizzirri, Giancarlo [1, 2] ; Souza Duran, Fabio Luis [1] ; Chaim-Avancini, Tiffany Moukbel [1] ; Serpa, Mauricio Henriques [1] ; Cavallet, Mikael [1] ; Abreu Pereira, Carla Maria [2] ; Santos, Pedro Paim [1] ; Squarzoni, Paula [1] ; da Costa, Naomi Antunes [1] ; Busatto, Geraldo F. [1, 2] ; Najjar Abdo, Carmita Helena [2]
Total Authors: 11
[1] Univ Sao Paulo NAPNA USP, Lab Neuroimage Psychiat LIM 21, Res Appl Neurosci, Support Core, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch FMUSP, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JAN 15 2018.
Web of Science Citations: 4

Many previous magnetic resonance imaging (MRI) studies have documented sex differences in brain morphology, but the patterns of sexual brain differences in transgender women - male sex assigned at birth - with a diagnosis of gender dysphoria (TW) have been rarely investigated to date. We acquired T1-weighted MRI data for the following four (n = 80) groups: treatment-naive TW (TNTW), TW treated with cross-sex hormones for at least one year (TTW), cisgender men, and cisgender women (cisgender individuals as controls). Differences in whole-brain and regional white matter volume and grey matter volume (GMV) were assessed using voxel-based morphometry. We found lower global brain volumes and regional GMVs in a large portion of the posterior-superior frontal cortex in the cisgender women group than in the TTW and cisgender men groups. Additionally, both transgender groups exhibited lower bilateral insular GMVs than the cisgender women group. Our results highlight differences in the insula in both transgender groups; such differences may be characteristic of TW. Furthermore, these alterations in the insula could be related to the neural network of body perception and reflect the distress that accompanies gender dysphoria. (AU)

FAPESP's process: 12/19165-7 - Study on brain morphometry and diffusion tensor images of the microstructure of white matter in male to female transexuals before and during the Transgender process
Grantee:Carmita Helena Najjar Abdo
Support type: Regular Research Grants