| Full text | |
| Author(s): |
Paschoalin-Maurin, Tatiana
[1]
;
dos Anjos-Garcia, Tayllon
[1]
;
Falconi-Sobrinho, Luiz Luciano
[1]
;
de Freitas, Renato Leonardo
[1, 2, 3]
;
Cysne Coimbra, Jade Pissamiglio
[1, 4]
;
Laure, Carlos Julio
[1, 4]
;
Coimbra, Norberto Cysne
[1, 2, 4, 5, 6]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Multiuser Ctr Neurophysiol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Lab Pain & Emot, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Ophidiarium LNN FMRP USP INeC, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Med Sch, NAP USP Neurobiol Emot Res Ctr NuPNE, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[6] Behav Neurosci Inst INeC, Av Cafe 2450, BR-14050220 Ribeirao Preto, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 369, p. 336-349, JAN 15 2018. |
| Web of Science Citations: | 10 |
| Abstract | |
Using an innovative approach to study the neural bases of psychiatric disorders, this study investigated the behavioral, morphological and pharmacological bases of panic attack-induced responses in a prey-versus-coral snake paradigm. Mesocricetus auratus was chronically treated with intraperitoneal administration of the selective serotonin uptake inhibitor paroxetine or the gamma aminobutyric acid (GABA)/benzodiazepine receptor agonist alprazolam at three different doses and were then confronted with a venomous coral snake (Micrurus frontalis, Reptilia, Elapidae). The threatened rodents exhibited defensive attention, flat back approaches, defensive immobility, and escape defensive responses in the presence of the venomous snake, followed by increases in Fos protein in limbic structure neurons. Chronic administration of both paroxetine and alprazolam decreased these responses with morphological correlates between the panicolytic effect of both drugs administered at the highest dose and decreases in Fos protein-immunolabeled perikarya found in the amygdaloid complex, hypothalamus and periaqueductal gray matter columns, which are structures that make up the encephalic aversion system. These findings provide face, construct and predictive validities of this new experimental model of anxiety-and panic attack-like behavioral responses displayed by threatened prey confronted with venomous coral snakes. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/17258-5 - Study of the involvement of nitrergic system and of glutamatergic and cannabinoid-mediated neurotransmission from the medial prefrontal cortex in the analgesia induced by elaborated escape reactions evoked by GABAergic blockade in the medial hypothalamus |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |