Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?

Author(s):Show less -

Salomao, Roberta Garcia ^[1] ; de Carvalho, Luciana Martins ^[1] ; Izumi, Clarice ^[2] ; Czernisz, Erika Silva ^[2] ; Rosa, Jose Cesar ^[2] ; Rauber Antonini, Sonir Roberto ^[1] ; Bueno, Ana Carolina ^[1] ; Ribeiro do Vale Almada, Maria Olimpia ^[1] ; Coelho-Landell, Carolina de Almeida ^[1] ; Jordao, Alceu Afonso ^[3] ; Leme Ferriani, Virginia Paes ^[1] ; Monteiro, Jacqueline Pontes ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Prot Chem Ctr, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Clin, Ribeirao Preto - Brazil

• Document type: Journal article
• Source: PEDIATRIC RHEUMATOLOGY; v. 16, JAN 9 2018.
• Web of Science Citations: 1

Abstract

Background: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-alpha, and hs-C reactive protein. Methods: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-alpha, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-alpha, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data. Results: Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-alpha, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-alpha and triglycerides and between hs-CRP and duration of corticosteroid therapy. Conclusion: Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP. (AU)

• FAPESP's process: 11/16141-7 - Plasma proteome and homocysteine in pediatric systemic lupus erythematosus
• Grantee: Jacqueline Pontes Monteiro
• Support Opportunities: Regular Research Grants