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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model

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Mano, Camila M. [1, 2, 3] ; Guaratini, Thais [2, 4] ; Cardozo, Karina H. M. [2, 5] ; Colepicolo, Pio [2] ; Bechara, Etelvino J. H. [6, 7] ; Barros, Marcelo P. [1, 8]
Total Authors: 6
[1] Univ Cruzeiro Sul, ICAFE, BR-01506000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo IQUSP, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP - Brazil
[3] Superintendencia Policia Tecn Cient, BR-05507060 Sao Paulo, SP - Brazil
[4] Lychnoflora Pesquisa & Dev Prod Nat LTDA, BR-14030090 Ribeirao Preto, SP - Brazil
[5] Grp Fleury, BR-04344070 Sao Paulo, SP - Brazil
[6] Univ Fed Sao Paulo, Dept Ciencias Exatas & Terra, UNIFESP, BR-09972270 Diadema, SP - Brazil
[7] Univ Sao Paulo IQUSP, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[8] CSIC, IATA, Dept Ciencia Alimentos, Calle Catedrat Agustin Escardino 7, Paterna 46980 - Spain
Total Affiliations: 8
Document type: Journal article
Source: MARINE DRUGS; v. 16, n. 4 APR 2018.
Web of Science Citations: 2

Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a ``mitochondrial-targeted{''} action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6.2 to 8.0), which were challenged by oxidizing/nitrating conditions that mimic the regular and preapoptotic redox environment of active mitochondria. Pre-apoptotic conditions were created by oxidized/nitr(osyl) ated cytochrome c and resulted in the highest levels of lipoperoxidation in both PCL and PCPGLs (pH 7.4). ASTA was less protective at acidic conditions, especially in anionic PCPGLs. Our data demonstrated the ability of ASTA to hamper oxidative and nitrative events that lead to cytochrome c-peroxidase apoptosis and lipid peroxidation, although its efficiency changes with pH and lipid composition of membranes. (AU)

FAPESP's process: 17/06032-2 - Biochemical, physiological and transcriptomic strategies to study the relationship between carotenoids, oxidative stress and Citrus fruit quality.
Grantee:Marcelo Paes de Barros
Support type: Scholarships abroad - Research