| Full text | |
| Author(s): |
Ataide, Janaina Artem
[1, 2]
;
Gerios, Eloah Favero
[3]
;
Mazzola, Priscila Gava
[3, 4]
;
Souto, Eliana B.
[2, 5]
Total Authors: 4
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Grad Program Med Sci, Campinas, SP - Brazil
[2] Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, Coimbra - Portugal
[3] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
[4] Univ Campinas Unicamp, Fac Pharmaceut Sci, Candido Portinari St, 200, Cidade Univ Zeferino Vaz, BR-13083871 Campinas, SP - Brazil
[5] REQUIMTE Grp Pharmaceut Technol, Coimbra - Portugal
Total Affiliations: 5
|
| Document type: | Review article |
| Source: | ADVANCES IN COLLOID AND INTERFACE SCIENCE; v. 254, p. 48-55, APR 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
Stem bromelain is a common available cysteine protease derived from pineapple (Ananas comosus L.). Bromelain finds widespread applications in several areas, such as medicine, health, food, and cosmetics, and its strong proteolytic activity supports its future application in many additional fields. However, most proteins and/or enzymes are fragile, leading to important considerations about increase storage and operational stability to enable their practical application. In this scenario, the use of nanoparticles to deliver proteins is increasing exponentially, given that these systems are capable of enhance active's stability, solubility and permeability, and decrease toxicity. In the pharmaceutical nanotechnology field, bromelain has played different roles and thus this paper aims to review the available literature for the use of nanoparticles and bromelain. (C) 2018 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 17/05333-9 - Bromelain encapsulation: characterization and stability |
| Grantee: | Eloah Favero Gérios |
| Support Opportunities: | Scholarships abroad - Research Internship - Scientific Initiation |
| FAPESP's process: | 16/03444-5 - Development of healing pharmaceutical formulation containing bromelain extracted from industrial wastes |
| Grantee: | Priscila Gava Mazzola |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/05275-9 - Bromelain encapsulation: stability, release profile, and cytotoxicity |
| Grantee: | Janaína Artem Ataide |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |