Purinergic system in psychiatric diseases

Author(s)

Cheffer, A. ^[1] ; Castillo, A. R. G. ^[1] ; Correa-Velloso, J. ^[1] ; Goncalves, M. C. B. ^[2] ; Naaldijk, Y. ^[1] ; Nascimento, I. C. ^[1] ; Burnstock, G. ^{[3, 4]} ; Ulrich, H. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Neurol Neurociencia, Escola Paulista Med, Sao Paulo - Brazil

^[3] Royal Free & Univ Coll Med Sch, Auton Neurosci Ctr, London - England

^[4] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic - Australia

• Document type: Review article
• Source: MOLECULAR PSYCHIATRY; v. 23, n. 1, p. 94-106, JAN 2018.
• Web of Science Citations: 21

Abstract

Psychiatric disorders are debilitating diseases, affecting > 80 million people worldwide. There are no causal cures for psychiatric disorders and available therapies only treat the symptoms. The etiology of psychiatric disorders is unknown, although it has been speculated to be a combination of environmental, stress and genetic factors. One of the neurotransmitter systems implicated in the biology of psychiatric disorders is the purinergic system. In this review, we performed a comprehensive search of the literature about the role and function of the purinergic system in the development and predisposition to psychiatric disorders, with a focus on depression, schizophrenia, bipolar disorder, autism, anxiety and attention deficit/hyperactivity disorder. We also describe how therapeutics used for psychiatric disorders act on the purinergic system. (AU)

• FAPESP's process: 15/14343-2 - Dental pulp derived mesenchymal stem cells and its conditioned medium: a novel therapeutic approach for ALS
• Grantee: Yahaira Maria Naaldijk Palma
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 15/18730-0 - Lung cancer stem cells by DNA aptamers identification / purification and kallikrein-kinin system study on tumor progression
• Grantee: Isis Cristina Corrêa Do Nascimento
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
• Grantee: Alexander Henning Ulrich
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 13/02293-5 - Aptamers inhibiting the protein CD73 as possible antitumoral agents
• Grantee: Arquimedes Cheffer
• Support type: Scholarships in Brazil - Post-Doctorate