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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory syncytial virus in Brazilian infants - Ten years, two cohorts

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Author(s):
Wollmeister, Elinara [1] ; Alvarez, Alfonso Eduardo [1, 2] ; Santiago Bastos, Juliana Cristina [3] ; Lima Marson, Fernando Augusto [4, 1, 2] ; Ribeiro, Jose Dirceu [1, 2] ; Elias Baracat, Emilio Carlos [1] ; Arns, Clarice Weis [3] ; Lopes Riccetto, Adriana Gut [1]
Total Authors: 8
Affiliation:
[1] Univ Campinas Unicamp, Fac Med Sci, Dept Pediat, Sao Paulo - Brazil
[2] Univ Campinas Unicamp, Fac Med Sci, Dept Pediat, Ctr Res Pediat CIPED, Sao Paulo - Brazil
[3] Univ Campinas Unicamp, Biol Inst, Dept Genet Evolut & Bioagents, Sao Paulo - Brazil
[4] Univ Campinas UNICAMP, Fac Med Sci, Dept Med Genet, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Clinical Virology; v. 98, p. 33-36, JAN 2018.
Web of Science Citations: 0
Abstract

Background: Each year, a considerable amount of children will experience at least one episode of acute viral bronchiolitis (AVB) during their first year of life. About 10% of them will be hospitalized, with significant physical and economic burdens. Objectives: To compare two cohorts of infants with AVB, from same region, in a ten-year interval, regarding epidemiologic factors and viral etiology. Study design: Cohorts: 142 (2004) and 172 (2014) infants at ages zero to 12 months; clinical diagnosis of AVB; medical care in hospital and genetic screening of nasopharyngeal secretion for respiratory viruses. Results: The comparative analysis showed a difference in the percentage of respiratory syncytial virus (RSV) positive patients {[}2004 (33.1%); 2014 (70.3%)] (p < 0.01). No differences were noted regarding gender, breastfeeding, tobacco exposure, crowding and maternal education. There was a difference as to the month of incidence (seasonality) of AVB (higher in April 2014). There was a higher age at attendance in the first cohort, and lower birth weight and gestational age ratios in the second cohort (p < 0.05). There were no differences in hospitalization time, need of mechanical ventilation and number of deaths, however a difference regarding co-morbidities was noted (higher in 2004) (p < 0.001). Conclusion: None of the analyzed variables had an impact on severity features. Virology and immunology must be considered in this kind of situation, by studying genetic variants and the maturation of the immune system in AVB by RSV or other viruses. (AU)

FAPESP's process: 11/12939-4 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic: mild, moderate and severe asthma
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/12183-8 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants
FAPESP's process: 11/18845-1 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic mild, moderate and severe asthma
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants
FAPESP's process: 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Post-Doctorate