Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis

Author(s):Show less -

Vincentiis, Silvia ^{[1, 2, 3]} ; Alcantara, Juliana ^[1] ; Rzezak, Patricia ^{[1, 2]} ; Kerr, Daniel S. ^{[3, 4]} ; Gattaz, Wagner F. ^[4] ; van der Linden, Jr., Helio ^[5] ; dos Santos, Bernardo ^[6] ; Melo-Souza, Sebastiao E. ^[5] ; Arruda, Francisco ^[5] ; Ragazzo, Paulo ^[5] ; Chaim-Avancini, Tiffany ^[2] ; Serpa, Mauricio H. ^[2] ; Fernandes, Fernando ^[7] ; Moreno, Ricardo A. ^[7] ; Busatto, Geraldo ^{[2, 3]} ; Alessi, Ruda ^[1] ; Demarque, Renata ^[1] ; Valente, Kette D. ^{[1, 2, 3]}

Affiliation

^[1] Univ Sao Paulo, Grp Study Cognit & Psychiat Disorders Epilepsy, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Lab Psychiat Neuroimaging LIM 21, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Lab Neurosci LIM 27, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[5] Goiania Neurol Inst, Setor Bueno, Praca Gilson Alves de Souza 140, BR-74210250 Goiania, Go - Brazil

^[6] Univ Sao Paulo, Nursing Sch, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Mood Disorders Unit GRUDA, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Epilepsy & Behavior; v. 83, p. 181-185, JUN 2018.
• Web of Science Citations: 1

Abstract

Background: Temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS) is the most frequent form of drug-resistant epilepsy in adults. Mood disorders are the most frequent psychiatric comorbidities observed in these patients. Common pathophysiological mechanisms of epilepsy and psychiatric comorbidities include abnormalities in the serotonin pathway. The primary goal of this study was to determine the possible association between polymorphisms of genes encoding the serotonin receptors 5HT1A (rs6295), 5HT1B (rs6296), and 5HT2C (rs6318) and the presence of mood disorders in patients with TLE-HS. Our secondary goal was to evaluate the possible association between these variants and susceptibility to develop seizures in TLE-HS. Methods: We assessed 119 patients with TLE-HS, with and without psychiatric comorbidities; 146 patients with major depressive disorder; and 113 healthy volunteers. Individuals were genotyped for the rs6295, rs6296, and rs6318 polymorphisms. Results: No difference was observed between the group with TLE-HS, healthy controls, and the group with major depressive disorder without epilepsy regarding the polymorphisms that were evaluated. There was no correlation between rs6318, rs6295, rs6296, and epilepsy-related factors and history of psychiatric comorbidities. Conclusions: Our work suggests that the studied polymorphisms were not related to the presence of TLE, psychiatric comorbidities in TLE, and epilepsy-related factors. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 13/11361-4 - Association study of polymorphisms in serotoninergic pathway and temporal lobe epilepsy caused by hippocampal sclerosis
• Grantee: Kette Dualibi Ramos Valente
• Support Opportunities: Regular Research Grants