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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In situ effect of the combination of fluoridated toothpaste and fluoridated gel containing sodium trimetaphosphate on enamel demineralization

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Akabane, Sara [1] ; Delbem, Alberto Carlos [1] ; Pessan, Juliano [1] ; Garcia, Luhana [1] ; Emerenciano, Nayara [1] ; Goncalves, Diego Felipe [1] ; Danelon, Marcelle [1]
Total Authors: 7
[1] Sao Paulo State Univ, Aracatuba Dept Pediat Dent & Publ Hlth, Sch Dent, UNESP, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Dentistry; v. 68, p. 59-65, JAN 2018.
Web of Science Citations: 3

Objective: This in situ study evaluated the effect of the association of low-F (4500 mu g F/g) gel containing TMP and FT (1100 mu g F/g) on enamel demineralization. Methods: This crossover and double-blind study consisted of five phases of seven days each. Volunteers (n = 12) wore palatal appliances containing four enamel blocks. The cariogenic challenge was performed with 30% sucrose solution (six times/day). Treatments were: placebo toothpaste (PT, no fluoride/TMP); 1100 mu g F/g toothpaste (FT); FT + 4500 mu g F/g+ 5% TMP gel (FT + TMP gel); FT + 9000 mu g F/g gel (FT + 9000 gel) and FT + 12,300 mu g F/g (FT + Acid gel). After topical application of treatments for one min, two blocks were removed for analysis of loosely bound fluoride (CaF2), calcium (Ca), phosphorus (P) and firmly bound fluoride (FA) formed in enamel. After the seven-day experimental periods, the percentage of surface hardness loss (% SH), integrated subsurface hardness loss (Delta KHN), CaF2, Ca, P and FA retained were determined. Moreover, the biofilms formed on the blocks were analyzed for F, Ca, P and insoluble extracellular polysaccharide (EPS) concentrations. Results: FT + TMP gel promoted the lowest% SH and Delta KHN (p < 0.001). The highest concentration of CaF2 formed was observed for the FT + Acid gel (p < 0.001), followed by FT + 9000 gel > FT + TMP gel > FT> PT. CaF2 retained on the blocks was reduced across all groups (p < 0.001). Similar values were observed for the Ca/P/F and EPS in enamel and biofilm for all fluoride groups. Conclusion: The association of FT + TMP gel significantly reduced enamel demineralization in situ. Clinical Significance: The association of treatments may be an alternative for patients with high caries risk. (AU)

FAPESP's process: 15/04041-9 - Effectiveness evaluation of a gel with low concentration fluoride supplemented with sodium trimetaphosphate on demineralization enamel dental: study in situ
Grantee:Sara Tiemi Felipe Akabane
Support type: Scholarships in Brazil - Scientific Initiation