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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties

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Author(s):
Ataide, Janaina Artem [1] ; de Carvalho, Nathalia Mendes [2] ; Rebelo, Marcia de Araujo [3] ; Chaud, Marco Vinicius [3] ; Grotto, Denise [2] ; Gerenutti, Marli [2] ; Rai, Mahendra [4] ; Mazzola, Priscila Gava [5] ; Jozala, Angela Faustino [2]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Grad Program Med Sci, Campinas, SP - Brazil
[2] Univ Sorocaba, Dept Technol & Environm Proc, Sorocaba, SP - Brazil
[3] Univ Sorocaba, LaBNUS, Biomat & Nanotechnol Lab, Sorocaba, SP - Brazil
[4] SGB Amravati Univ, Dept Biotechnol, Nanobiotechnol Lab, Amravati, Maharashtra - India
[5] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, DEC 21 2017.
Web of Science Citations: 7
Abstract

Bacterial nanocellulose (BNC) has desirable properties for wound healing such as high purity, good shape retention, and high water binding capacity. Bromelain is a protease found in pineapple tissues and has been applied in several fields, it has anti-inflammatory and anticancer properties, promotes cell apoptosis, amongst others. In this work, a BNC based device for the controlled release of bromelain was developed. BNC were submersed in sterilized bromelain solution and incubated at 25 degrees C under 100 rpm for 24 h. Physical-chemical properties, protein concentration, antioxidant and antimicrobial activities were measured. Results demonstrate that BNC could improve bromelain antimicrobial activity 9 times. Those findings allow concluding that bromelain is a promising molecule to be incorporated into BNC's. The BNC's characteristics seem to represent a new promising delivery system of the loaded biomolecule, and protected from external actions. (AU)

FAPESP's process: 11/23076-7 - Bromelain extraction from pineapple residues using ethanol precipitation and its application in polymeric hydrogel
Grantee:Janaína Artem Ataide
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/05930-4 - Development of a Production and Purification Platform for Bioproducts
Grantee:Angela Faustino Jozala
Support Opportunities: Regular Research Grants