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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High prevalence of metabolic syndrome in antisynthetase syndrome

Author(s):
Araujo, P. A. O. [1] ; Silva, M. G. [1] ; Borba, E. F. [1] ; Shinjo, S. K. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; v. 36, n. 2, p. 241-247, MAR-APR 2018.
Web of Science Citations: 4
Abstract

Objective A high frequency of metabolic syndrome (MetS) has been recently described in different idiopathic inflammatory myopathies, but not in antisynthetase syndrome (ASS). Therefore, the aim of the present study was to determine the prevalence of MetS in ASS and also its possible association with cardiovascular the risk factors and ASS-related disease characteristics. Methods A cross-sectional single centre study of 42 consecutive ASS patients was conducted from 2012 to 2015 and compared to 84 healthy individuals matched for gender, age, ethnicity and body mass index-matched (control group). MetS was defined according to the 2009 Join Interim Statement. Clinical and laboratory data were assessed according to a standardised protocol. Results ASS patients had a median age of 41.1 years with a predominance of female gender and white race. ASS patients had a higher frequency of MetS (42.9% vs. 13.1%; p<0.001) as well as of insulin resistance than controls. Moreover, ASS patients had higher resistin, lower leptin and similar adiponectin levels in serum than controls. Further analysis of ASS patients with (n=18) and without (n=24) MetS revealed that older age at disease onset (48.7 vs. 35.4 years; p<0.001) was identified in those with the syndrome but were similar regarding disease duration, disease status, treatment, insulin resistance and serum adipocytokine levels. Conclusion The prevalence of MetS was high in ASS patients that also had serum resistin and low leptin levels. As also identified in other idiopathic inflammatory myopathies, MetS in ASS is more prevalent in older patients. (AU)

FAPESP's process: 12/07101-4 - Serum cytokines and its gene expression: correlation with clinical and laboratory features and metabolic alterations of dermatomyositis/polymyositis
Grantee:Samuel Katsuyuki Shinjo
Support type: Regular Research Grants