Palladium-catalyzed C-H alkenylation of quinoxaline N-oxide enabled by a mono-N-protected amino acid

Author(s)

Freire Franco, Marcia Silvana ^[1] ; de Paula, Murilo Helder ^[1] ; Glowacka, Paulina Cecylia ^[1] ; Fumagalli, Fernando ^[1] ; Clososki, Giuliano Cesar ^[1] ; Emery, Flavio da Silva ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Tetrahedron Letters; v. 59, n. 26, p. 2562-2566, JUN 27 2018.
• Web of Science Citations: 1

Abstract

The efficient alkenylation of quinoxaline N-oxide was achieved via Pd-catalyzed C-H activation, using the assistance of a mono-N-protected amino acid. Further deoxygenation of the 2-styrylquinoxaline-N-oxides yielded the corresponding styrylquinoxaline derivatives. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

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