Development of the first experimental model of Ilheus Virus (ILHV) infection in mi...
| Full text | |
| Author(s): Show less - |
Amarilla, Alberto Anastacio
[1, 2]
;
Fumagalli, Marcilio Jorge
[3]
;
Figueiredo, Mario Luis
[1]
;
Lima-Junior, Djalma S.
[4]
;
Santos-Junior, Nilton Nascimento
[5]
;
Alfonso, Helda Liz
[1]
;
Lippi, Veronica
[1]
;
Trabuco, Amanda Cristina
[1]
;
Lauretti, Flavio
[3]
;
Muller, Vanessa Danielle
[1]
;
Colon, David F.
[6]
;
Luiz, Joao P. M.
[6]
;
Suhrbier, Andreas
[7, 2]
;
Setoh, Yin Xiang
[2]
;
Khromykh, Alexander A.
[2]
;
Moraes Figueiredo, Luiz Tadeu
[3]
;
Aquino, Victor Hugo
[1]
Total Authors: 17
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Lab Virol, Ribeirao Preto, SP - Brazil
[2] Univ Queensland, Australian Infect Dis Res Ctr, Sch Chem & Mol Biosci, St Lucia, Qld - Australia
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Lab Inflammat & Pain, Dept Immunol, Ribeirao Preto, SP - Brazil
[7] QIMR Berghofer Med Res Inst, Brisbane, Qld - Australia
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | PLoS One; v. 13, n. 6 JUN 13 2018. |
| Web of Science Citations: | 4 |
| Abstract | |
Rocio virus (ROCV) was the causative agent of an unprecedented outbreak of encephalitis during the 1970s in the Vale do Ribeira, Sao Paulo State, in the Southeast region of Brazil. Surprisingly, no further cases of ROCV infection were identified after this outbreak; however, serological surveys have suggested the circulation of ROCV among humans and animals in different regions of Brazil. Cross-protective immunity among flaviviruses is well documented; consequently, immunity induced by infections with other flaviviruses endemic to Brazil could potentially be responsible for the lack of ROCV infections. Herein, we evaluated the cross-protection mediated by other flaviviruses against ROCV infection using an experimental C57BU6 mouse model. Cross-protection against ROCV infection was observed when animals had prior exposure to Ilheus virus or Saint Louis encephalitis virus, suggesting that cross-reactive anti-flavivirus antibodies may limit ROCV disease outbreaks. (AU) | |
| FAPESP's process: | 14/02438-6 - Studies with Bunyaviridae that produce human disease |
| Grantee: | Luiz Tadeu Moraes Figueiredo |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/08778-8 - Analysis of participation the e protein in neuroinvasiveness and neurovirulence of Rocio Virus in an animal model |
| Grantee: | Alberto Anastacio Amarilla Ortiz |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 14/15548-4 - Study of viruses transmitted by rodents and arthropods: diagnosis and cross-protection |
| Grantee: | Victor Hugo Aquino Quintana |
| Support type: | Regular Research Grants |