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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice

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Amarilla, Alberto Anastacio [1, 2] ; Fumagalli, Marcilio Jorge [3] ; Figueiredo, Mario Luis [1] ; Lima-Junior, Djalma S. [4] ; Santos-Junior, Nilton Nascimento [5] ; Alfonso, Helda Liz [1] ; Lippi, Veronica [1] ; Trabuco, Amanda Cristina [1] ; Lauretti, Flavio [3] ; Muller, Vanessa Danielle [1] ; Colon, David F. [6] ; Luiz, Joao P. M. [6] ; Suhrbier, Andreas [7, 2] ; Setoh, Yin Xiang [2] ; Khromykh, Alexander A. [2] ; Moraes Figueiredo, Luiz Tadeu [3] ; Aquino, Victor Hugo [1]
Total Authors: 17
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Lab Virol, Ribeirao Preto, SP - Brazil
[2] Univ Queensland, Australian Infect Dis Res Ctr, Sch Chem & Mol Biosci, St Lucia, Qld - Australia
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Lab Inflammat & Pain, Dept Immunol, Ribeirao Preto, SP - Brazil
[7] QIMR Berghofer Med Res Inst, Brisbane, Qld - Australia
Total Affiliations: 7
Document type: Journal article
Source: PLoS One; v. 13, n. 6 JUN 13 2018.
Web of Science Citations: 4

Rocio virus (ROCV) was the causative agent of an unprecedented outbreak of encephalitis during the 1970s in the Vale do Ribeira, Sao Paulo State, in the Southeast region of Brazil. Surprisingly, no further cases of ROCV infection were identified after this outbreak; however, serological surveys have suggested the circulation of ROCV among humans and animals in different regions of Brazil. Cross-protective immunity among flaviviruses is well documented; consequently, immunity induced by infections with other flaviviruses endemic to Brazil could potentially be responsible for the lack of ROCV infections. Herein, we evaluated the cross-protection mediated by other flaviviruses against ROCV infection using an experimental C57BU6 mouse model. Cross-protection against ROCV infection was observed when animals had prior exposure to Ilheus virus or Saint Louis encephalitis virus, suggesting that cross-reactive anti-flavivirus antibodies may limit ROCV disease outbreaks. (AU)

FAPESP's process: 14/02438-6 - Studies with Bunyaviridae that produce human disease
Grantee:Luiz Tadeu Moraes Figueiredo
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/08778-8 - Analysis of participation the e protein in neuroinvasiveness and neurovirulence of Rocio Virus in an animal model
Grantee:Alberto Anastacio Amarilla Ortiz
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/15548-4 - Study of viruses transmitted by rodents and arthropods: diagnosis and cross-protection
Grantee:Victor Hugo Aquino Quintana
Support type: Regular Research Grants