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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of parabens on antioxidant system and oxidative damages in Nile tilapia (Oreochromis niloticus)

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Author(s):
Silva, Daniele C. [1] ; Serrano, Lenard [1] ; Oliveira, Thiessa M. A. [1] ; Mansano, Adrislaine S. [2] ; Almeida, Eduardo A. [3] ; Vieira, Eny M. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Chem, Av Trabalhador Sao Carlene 400, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Ecol & Evolutionary Biol, Rodovia Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[3] Paulista State Univ IBILCE UNESP, Dept Chem & Environm Sci, Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY; v. 162, p. 85-91, OCT 30 2018.
Web of Science Citations: 4
Abstract

In this study, effects of parabens on antioxidant defenses and oxidative damages in gills and liver of Nile tilapia (Oreochromis niloticus) were evaluated. Adult Nile tilapia were exposed to methyl, ethyl, propyl, butyl and benzylparaben and a mixture of methyl and propylparaben for 6 and 12 days. The biomarkers analyzed were superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), total glutathione (GSH-t) and lipid peroxidation measured by malondialdehyde (MDA) content. Results indicated that exposure to parabens caused biochemical changes in gill and liver cells, which in turn modulated enzymatic and non-enzymatic antioxidants in Nile tilapia. SOD, GPx and GR activity significantly increased in gills and liver after exposure to most parabens. CAT activity had little (liver) or no alteration (gills) in this fish species after treatment with parabens. GSH-t content in liver decreased after 6 days of exposure to parabens, but after 12 days, GSH-t levels increased in liver in all treatments, indicating an antioxidant adaptation to exposure to sublethal doses of parabens. Regarding the MDA levels, no alterations were observed in gills compared to control and in liver the MDA content was reduced after 12d of exposure to ethylparaben, butylparaben and paraben mixture, indicating no lipid peroxidation in the analyzed tissues. Our results demonstrate parabens-induced adaptive responses in fish, which were important in the protection against oxidative damages. (AU)

FAPESP's process: 12/01192-8 - Development, validation and application of analytical method to determine parabens in water and in different tissues of Nile Tilapia (Oreochromis niloticus) and evaluation of effects on biochemical biomarkers
Grantee:Eny Maria Vieira
Support type: Regular Research Grants
FAPESP's process: 12/00150-0 - Development, validation and application of analytical method to determine parabens in water and in different tissues of Nile Tilapia (Oreochromis niloticus) and evaluation of effects on biochemical biomarkers
Grantee:Daniele Caetano da Silva
Support type: Scholarships in Brazil - Doctorate