| Full text | |
| Author(s): |
Vieira, Tatiana M.
[1]
;
dos Santos, Isabella A.
[1]
;
Silva, Thayna S.
[2]
;
Martins, Carlos H. G.
[2]
;
Crotti, Antonio E. M.
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Franca, Lab Pesquisa Microbiol Aplicada, Ave Dr Armando Salles de Oliveira, 201 Parque Univ, BR-14404600 Franca, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | CHEMISTRY & BIODIVERSITY; v. 15, n. 8 AUG 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC=50g/ml) and Streptococcus mitis (MIC=50g/ml) as well as moderate activity against S.sanguinis (MIC=100g/ml), Lactobacillus casei (MIC=100g/ml), and Streptococcus salivarius (MIC=200g/ml). Results indicated higher activity of compound 10 than that of its bis--diketone analog. Additionally, compounds 3a (1,5-bis(4-methylphenyl)pentan-3-one) and 7b (1,5-bis(4-bromophenyl)pentan-3-ol) were moderately active against S.mitis (MIC=100g/ml) and S.salivarus (MIC=200g/ml). (AU) | |
| FAPESP's process: | 13/20094-0 - Evaluation of the anti-parasitary and insecticidal activities of benzofuran derivatives, and study of their gas-phase fragmentation reactions using tandem mass spectrometry |
| Grantee: | Antônio Eduardo Miller Crotti |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/19272-9 - Evaluation of the antimicrobial activity of curcuminoids and study of their fragmentation reactions in the gas-phase by tandem mass spectrometry |
| Grantee: | Tatiana Manzini Vieira |
| Support Opportunities: | Scholarships in Brazil - Master |