Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria

Author(s)

Vieira, Tatiana M. ^[1] ; dos Santos, Isabella A. ^[1] ; Silva, Thayna S. ^[2] ; Martins, Carlos H. G. ^[2] ; Crotti, Antonio E. M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

^[2] Univ Franca, Lab Pesquisa Microbiol Aplicada, Ave Dr Armando Salles de Oliveira, 201 Parque Univ, BR-14404600 Franca, SP - Brazil

• Document type: Journal article
• Source: CHEMISTRY & BIODIVERSITY; v. 15, n. 8 AUG 2018.
• Web of Science Citations: 0

Abstract

We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC=50g/ml) and Streptococcus mitis (MIC=50g/ml) as well as moderate activity against S.sanguinis (MIC=100g/ml), Lactobacillus casei (MIC=100g/ml), and Streptococcus salivarius (MIC=200g/ml). Results indicated higher activity of compound 10 than that of its bis--diketone analog. Additionally, compounds 3a (1,5-bis(4-methylphenyl)pentan-3-one) and 7b (1,5-bis(4-bromophenyl)pentan-3-ol) were moderately active against S.mitis (MIC=100g/ml) and S.salivarus (MIC=200g/ml). (AU)

• FAPESP's process: 13/20094-0 - Evaluation of the anti-parasitary and insecticidal activities of benzofuran derivatives, and study of their gas-phase fragmentation reactions using tandem mass spectrometry
• Grantee: Antônio Eduardo Miller Crotti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/19272-9 - Evaluation of the antimicrobial activity of curcuminoids and study of their fragmentation reactions in the gas-phase by tandem mass spectrometry
• Grantee: Tatiana Manzini Vieira
• Support Opportunities: Scholarships in Brazil - Master