Oocyte mitochondria: role on fertility and disease transmission

Author(s):Show less -

Chiaratti, Marcos R. ^{[1, 2]} ; Garcia, Bruna M. ^[2] ; Carvalho, Karen F. ^[2] ; Macabelli, Carolina H. ^[2] ; da Silva Ribeiro, Fernanda Karina ^[2] ; Zangirolamo, Amanda F. ^[3] ; Sarapiao, Fabiana D. ^[3] ; Seneda, Marcelo M. ^[3] ; Meirelles, Flavio V. ^{[1, 4]} ; Guimaraes, Francisco E. G. ^[5] ; Machado, Thiago S. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Genet & Evolucao, Sao Carlos, SP - Brazil

^[3] Univ Estadual Londrina, Londrina, PR - Brazil

^[4] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Pirassununga, SP - Brazil

^[5] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ANIMAL REPRODUCTION; v. 15, n. 3, p. 231-238, JUL-SEP 2018.
• Web of Science Citations: 0

Abstract

Oocyte mitochondria are increased in number, smaller, and rounder in appearance than mitochondria in somatic cells. Moreover, mitochondrial numbers and activity are narrowly tied with oocyte quality because of the key role of mitochondria to oocyte maturation. During oocyte maturation, mitochondria display great mobility and cluster at specific sites to meet the high energy demand. Conversely, oocyte mitochondria are not required during early oogenesis as coupling with granulosa cells is sufficient to support gamete's needs. In part, this might be explained by the importance of protecting mitochondria from oxidative damage that result in mutations in mitochondrial DNA (mtDNA). Considering mitochondria are transmitted exclusively by the mother, oocytes with mtDNA mutations may lead to diseases in offspring. Thus, to counterbalance mutation expansion, the oocyte has developed specific mechanisms to filter out deleterious mtDNA molecules. Herein, we discuss the role of mitochondria on oocyte developmental potential and recent evidence supporting a purifying filter against deleterious mtDNA mutations in oocytes. (AU)

• FAPESP's process: 16/07868-4 - Effect of the mitofusins knockout on the inheritance of deleterious Mitochondrial DNA in mouse embryionic fibroblasts
• Grantee: Carolina Habermann Macabelli
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/05899-2 - Effect of the knockout of mitofusins on mouse oocyte: implications to fertility and mitochondrial inheritance
• Grantee: Marcos Roberto Chiaratti
• Support type: Regular Research Grants
• FAPESP's process: 12/50231-6 - Molecular basis of mitochondrial inheritance: the role of mitochondrial fusion
• Grantee: Marcos Roberto Chiaratti
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 16/11942-5 - Fertility effect of the knockout of Mitofusin 1 on murine oocytes
• Grantee: Karen Freire Carvalho
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 16/11935-9 - Effect of the knockout of Mitofusin 2 on mitochondria, endoplasmic reticulum and mitophagy in murine oocytes
• Grantee: Bruna Martins Garcia
• Support type: Scholarships in Brazil - Master