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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Glucose tolerant and glucose stimulated beta-glucosidases - A review

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Author(s):
Santos Salgado, Jose Carlos [1] ; Meleiro, Luana Parras [1] ; Carli, Sibeli [1] ; Ward, Richard John [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Bioresource Technology; v. 267, p. 704-713, NOV 2018.
Web of Science Citations: 15
Abstract

The beta-glucosidases (beta-D-glucoside glucohydrolase, EC 3.2.1.21) hydrolyze glycosidic bonds of alkyl-, amino-, or aryl-beta-D-glucosides, cyanogenic glucosides, disaccharides and short oligosaccharides and can also catalyze the synthesis of glycosyl-bonds between different molecules via transglycosylation. Due to their ubiquitous phylogenetic distribution, substrate diversity and ability to both hydrolyze and synthesize glycosidic bonds, the catalysis and regulation of beta-glucosidases have been extensively studied. Many beta-glucosidases are inhibited by the reaction product glucose, and reduced catalytic activity may limit the biotechnological and industrial applications of these enzymes and this has stimulated the search for beta-glucosidases that maintain their activity at high glucose concentrations. Studies of many glucose tolerant enzymes have been reported and due to the ongoing interest in these enzymes, here it has been reviewed this accumulated body of knowledge which provides valuable insights as to the kinetics, structure, regulation and evolution of glucose tolerant and glucose stimulated beta-glucosidases. (AU)

FAPESP's process: 17/13734-3 - Engineering of an endopolygalacturonase by insertion of different Carbohydrate Binding Modules (CBMs): chimerogenesis and proximity effects
Grantee:Sibeli de Carli
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50884-5 - INCT 2014: National Institute of Science and Technology of Bioethanol
Grantee:Marcos Silveira Buckeridge
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/17582-0 - Thermostability modulation of a ß-glucosidase stimulated by glucose and xylose using site directed glycosylation
Grantee:Luana Parras Meleiro Garcia
Support Opportunities: Scholarships in Brazil - Post-Doctoral