| Full text | |
| Author(s): |
Kim, Seung Wook
[1]
;
Wurm, Thomas
[1]
;
Brito, Gilmar A.
[1]
;
Jung, Woo-Ok
[1]
;
Zbieg, Jason R.
[2]
;
Stivala, Craig E.
[2]
;
Krische, Michael J.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Texas Austin, Dept Chem, Austin, TX 78712 - USA
[2] Genentech Inc, Discovery Chem, 1 DNA Way, San Francisco, CA 94080 - USA
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of the American Chemical Society; v. 140, n. 29, p. 9087-9090, JUL 25 2018. |
| Web of Science Citations: | 9 |
| Abstract | |
In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine. (AU) | |
| FAPESP's process: | 17/00734-5 - Catalytic synthesis of Type II polyketides via Hydrogen-Mediated C-C bond formation |
| Grantee: | Gilmar Araujo Brito Junior |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |