| Full text | |
| Author(s): |
Bastos, Marta Ferreira
[1]
;
de Franco, Leonardo
[1]
;
Garcia Tebar, Andressa Cristina
[1]
;
Giro, Gabriela
[1]
;
Shibli, Jamil Awad
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Guarulhos, Dept Periodontol & Oral Implantol, Dent Res Div, Guarulhos, SP - Brazil
[2] Univ Guarulhos, Oral Implantol Program, Guarulhos, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 33, n. 3, p. 565-570, MAY-JUN 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Purpose: To evaluate the gene expression levels of semaphorins 3A, 3B, 4A, and 4D in both healthy and diseased implants. Materials and Methods: Subjects with peri-implantitis presented clinical attachment loss, probing depth >= 5 mm, bleeding on probing and/or suppuration, and radiographic bone loss > 4 mm. Peri-implant tissue biopsy specimens were sampled for analysis of the m RNA expression levels for semaphorins 3A, 38, 4A, and 4D. A real-time polymerase chain reaction was performed, and the gene expression levels of semaphorins in relation to the housekeeping gene were analyzed by using the nonparametric Mann-Whitney test (P < .05). Results: Thirty-five subjects (16 men, 19 women; mean age: 54.12 +/- 2.34 years) with implant-supported restorations, using screw-shaped dental implants with internal or external hexagon were enrolled in this study. Nigher levels of semaphorins 3A and 4D were detected in the peri-implantitis compared with the healthy tissues (P = .0011 and P = .0404, respectively), whereas Sem4A levels were significantly higher in the control group (P < .0001). Differences between groups in the expression levels of Sem3B were not significant. Conclusion: Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. (AU) | |
| FAPESP's process: | 08/07154-5 - Immunological evaluation of surgical treatment of peri-implantitis using Er, Cr:YSGG associated with systemic antibiotics. |
| Grantee: | Luciana Aparecida de Gouveia Cardoso |
| Support Opportunities: | Scholarships in Brazil - Master |