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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review

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Author(s):
Gonsalves Silva, Luciana Miato [1] ; Zamuner, Luis Fernando [1] ; David, Amanda Cabral [1] ; dos Santos, Solange A. [2] ; Camilo de Carvalho, Paulo de Tarso [2] ; Zamuner, Stella Regina [1]
Total Authors: 6
Affiliation:
[1] Univ Nove Julho, Postgrad Program Med, UNINOVE SP, Sao Paulo - Brazil
[2] Univ Nove Julho, Postgrad Program Reabilitat Sci, UNINOVE SP, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Toxicon; v. 152, p. 23-29, SEP 15 2018.
Web of Science Citations: 2
Abstract

Bothrops snakebite treatment is antivenom therapy, which is ineffective in neutralizing the severe local effects caused by these envenomations. There are evidence that photobiomodulation therapy (PBMT) has emerged as a promising tool to counteract the venom-induced local effects. The purpose was to write a narrative review of the literature about PBMT as a treatment for Bothrops snakebites. We reviewed articles indexed in PubMed, SCOPUS and Scientif Direct database with filter application. Included studies had to investigate local effects induced by Bothrops snake venom in any animal model using any type of photobiomodulation irradiation and at least one quantitative measure of local effects of Bothrops envenomation. Sixteen studies were selected from 54 original articles targeted PBMT (low-level laser or light emitting diode) as a complementary tool for local effects treatment induced by snakebites, and all its assessments. Articles were critically assessed by two independent raters with a structured tool for rating the research quality. PBMT demonstrate to be a promising tool for local treatment effects caused by snakebite by reducing local edema, hyperalgesia, leukocyte influx and myonecrosis and accelerating tissue regeneration related to myotoxicity. However, the mechanism is not well understood and additional studies are needed. (AU)

FAPESP's process: 17/13503-1 - Effect of photobiomodulation on local reaction induced by Bothrops venom: mechanisms of muscle regeneration, inflammatory response and oxidative stress
Grantee:Stella Regina Zamuner
Support Opportunities: Regular Research Grants