Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

BGP-15 improves contractile function of regenerating soleus muscle

Full text
Nascimento, Tabata L. [1] ; Silva, Meiricris T. [1] ; Miyabara, Elen H. [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Av Prof Lineu Prestes 2415, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY; v. 39, n. 1-2, p. 25-34, APR 2018.
Web of Science Citations: 1

This study investigated the effect of the heat shock protein inducer O-{[}3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime (BGP-15) on the morphology and contractile function of regenerating soleus muscles from mice. Cryolesioned soleus muscles from young mice treated daily with BGP-15 (15mg/Kg) were evaluated on post-cryolesion day 10. At this time point, there was a significant decrease in the cross-sectional area of regenerating myofibers, maximal force, specific tetanic force, and fatigue resistance of regenerating soleus muscles. BGP-15 did not reverse the decrease in myofiber cross-sectional area but effectively prevented the reduction in tetanic force and fatigue resistance of regenerating muscles. In addition, BGP-15 treatment increased the expression of embryonic myosin heavy chain (e-MyHC), MyHC-II and MyHC-I in regenerating muscles. Although BGP-15 did not alter voltage dependent anion-selective channel 2 (VDAC2) expression in cryolesioned muscles, it was able to increase inducible 70-kDaheat shock protein(HSP70) expression. Our results suggest that BGP-15 improves strength recovery in regenerating soleus muscles by accelerating the re-expression of adult MyHC-II and MyHC-I isoforms and HSP70 induction. The beneficial effects of BGP-15 on the contractile function of regenerating muscles reinforce the potential of this molecule to be used as a therapeutic agent. (AU)

FAPESP's process: 14/13874-1 - Skeletal muscle regeneration in mice with Marfan Syndrome: study of the regenerative potential of satellite cells
Grantee:Meiricris Tomaz da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/23391-8 - Regenerative response of skeletal muscles from mice with Marfan Syndrome
Grantee:Elen Haruka Miyabara
Support Opportunities: Regular Research Grants
FAPESP's process: 13/04783-0 - The influence of heat shock proteins in the recovery of skeletal muscle of old mice
Grantee:Tábata Leal Nascimento
Support Opportunities: Scholarships in Brazil - Doctorate