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The influence of heat shock proteins in the recovery of skeletal muscle of old mice

Grant number: 13/04783-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): April 30, 2018
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Elen Haruka Miyabara
Grantee:Tábata Leal Nascimento
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/22802-0 - The influence of the inducible heat shock protein 70 kDa (HSP70) on myoblast differentiation: regulation by miRNAs, BE.EP.DR


During aging, there is a progressive decline of skeletal muscle mass and a remarkable deficit in the regenerative capacity of skeletal muscles. It is well known that this deficit in old skeletal muscle is associated with a decrease in the number and function of satellite cell and an increase of pro-inflammatory cytokines that are able to activate the Nuclear Transcription Factor Kappa B (NF-kB). This factor is able to induce the expression of Transforming Growth Factor ² (TGF-²), which is a fibrosis stimulator. Considering the ongoing increase of life expectancy and the importance of muscle integrity for the maintenance of life quality, there has been an increasing interest in the investigation of therapeutic strategy able to minimize the deleterious effects of aging on skeletal muscle. In this context, the study of possible therapeutic agents able to attenuate the deficit in the skeletal muscle recovery in old people is still ongoing. Good candidates are the heat shock proteins (HSPs), especially the heat shock protein 70 (HSP70), a cytoprotective protein able to attenuate muscle atrophy, muscle damage and to inhibit fibrosis process in dystrophic mice. Thus, these proteins could contribute to the reduction of the harmful effects of aging in skeletal muscle and to the improvement the muscle regenerative response in old individuals. Considering that the role of HSPs in muscle regeneration of old people is not well known, and that the treatment with BGP-15, an HSP inductor, attenuates the muscle fibrosis process; the overexpression of HSP in regenerating skeletal muscle, through the treatment with BGP-15, could improve the function of the satellite cells and/or attenuate the muscle fibrosis process. Therefore, the aim of this work is to investigate the influence of HSPs in skeletal muscle regeneration of old individuals through the analysis of the effects of BGP-15 treatment in structural, molecular and functional aspects of skeletal muscle regeneration of old mice. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, T. L.; CONTE, T. C.; RISSATO, T. S.; LUNA, M. S.; SOARES, A. G.; MORISCOT, A. S.; YAMANOUYE, N.; MIYABARA, E. H.. Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation. Toxicon, v. 167, p. 6-9, . (13/04783-0, 12/21238-2, 09/53528-7)
SILVA, MEIRICRIS T.; NASCIMENTO, TABATA L.; PEREIRA, MARCELO G.; SIQUEIRA, ADRIANE S.; BRUM, PATRICIA C.; JAEGER, RUY G.; MIYABARA, ELEN H.. beta 2-Adrenoceptor is involved in connective tissue remodeling in regenerating muscles by decreasing the activity of MMP-9. Cell and Tissue Research, v. 365, n. 1, p. 173-186, . (14/13874-1, 14/23391-8, 13/04783-0, 12/21238-2)
DA SILVA, MEIRICRIS TOMAZ; SANTOS, AUDREI R.; KOIKE, TATIANA E.; NASCIMENTO, TABATA L.; ROZANSKI, ANDREI; BOSNAKOVSKI, DARKO; PEREIRA, LYGIA, V; KUMAR, ASHOK; KYBA, MICHAEL; MIYABARA, ELEN H.. The fibrotic niche impairs satellite cell function and muscle regeneration in mouse models of Marfan syndrome. ACTA PHYSIOLOGICA, v. 237, n. 1, p. 19-pg., . (17/14115-5, 20/15351-7, 18/24946-4, 17/09069-4, 14/23391-8, 13/04783-0, 14/13874-1)
NASCIMENTO, TABATA L.; SILVA, MEIRICRIS T.; MIYABARA, ELEN H.. BGP-15 improves contractile function of regenerating soleus muscle. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, v. 39, n. 1-2, p. 25-34, . (14/13874-1, 14/23391-8, 13/04783-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NASCIMENTO, Tábata Leal. Influence of heat shock proteins on skeletal muscle regeneration of old mice.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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