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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis and characterization of zinc substituted magnetite nanoparticles and their application to magneto-motive ultrasound imaging

Full text
Author(s):
Hadadian, Yaser [1] ; Sampaio, Diego R. T. [1] ; Ramos, Ana P. [2] ; Carneiro, Antonio A. O. [1] ; Mozaffari, Morteza [3] ; Cabrelli, Luciana C. [1] ; Pavan, Theo Z. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Fis, FFCLRP, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Dept Quim, FFCLRP, Ribeirao Preto - Brazil
[3] Univ Isfahan, Fac Sci, Dept Phys, Esfahan - Iran
Total Affiliations: 3
Document type: Journal article
Source: Journal of Magnetism and Magnetic Materials; v. 465, p. 33-43, NOV 1 2018.
Web of Science Citations: 3
Abstract

Biomedical application of magnetic nanoparticles is a rapidly growing research field. For medical diagnostic purposes, these nanoparticles are mostly used as imaging contrast agents. Magneto-motive ultrasound (MMUS) is an example of imaging techniques where superparamagnetic nanoparticles are used as contrast agent. Since it is a relatively new technique, much research is yet in progress to optimize the magnetic properties of these contrast agents. In this study, Zn-substituted magnetic (nominal composition ZnxFe1-xFe2O4, x=0.0, 0.1, 0.2, 0.3 and 0.4) nanoparticles with aim of enhancing the saturation magnetization were successfully synthesized by the coprecipitation method. The effect of zinc on morphology, structure and magnetic properties of the prepared nanoparticles was studied and their potential for MMUS imaging was investigated. X-Ray diffraction results showed that all samples had spinel structure and incorporating zinc in magnetite structure led to an increase in its lattice parameter, on the other hand TEM images revealed that particle size was decreased with zinc concentration. EDX analysis of the samples confirmed the incorporation of zinc in magnetite structure with a relatively good agreement with nominal values. Low, room and high temperature magnetic properties of the samples were investigated using vibrating sample magnetometer (VSM). Room temperature M-H curves along with zero-field-cooling measurements showed all samples were superparamagnetic and saturation magnetization at x=0.1 zinc concentration increased drastically. All prepared samples were examined as contrast agents in MMUS imaging and the results confirmed the direct role of magnetization in enhancement of MMUS signals. (AU)

FAPESP's process: 09/54082-2 - Acquisition of a vibranting sample magnetometer coupled with a superconducting quantum interference device assensor (Squid-VSM) with cryogenic closed cycle
Grantee:Ernesto Chaves Pereira de Souza
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization
Grantee:Theo Zeferino Pavan
Support Opportunities: Research Grants - Young Investigators Grants