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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

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Author(s):
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Golan, Karin [1] ; Kumari, Anju [1] ; Kollet, Orit [1] ; Khatib-Massalha, Eman [1] ; Subramaniam, Mohana Devi [1] ; Ferreira, Zulma S. [2] ; Avemaria, Francesca [1] ; Rzeszotek, Sylwia [3] ; Garcia-Garcia, Andres [4] ; Xie, Stephanie [5] ; Flores-Figueroa, Eugenia [5, 6] ; Gur-Cohen, Shiri [1] ; Itkin, Tomer [1] ; Ludin-Tal, Aya [1] ; Massalha, Hassan [7] ; Bernshtein, Biana [1] ; Ciechanowicz, Andrzej K. [8] ; Brandis, Alexander [9] ; Mehlman, Tevie [9] ; Bhattacharya, Suditi [1] ; Bertagna, Mayla [1] ; Cheng, Hui [10, 11, 12] ; Petrovich-Kopitman, Ekaterina [9] ; Janus, Tomasz [13] ; Kaushansky, Nathali [1] ; Cheng, Tao [10, 11, 12] ; Sagi, Irit [14] ; Ratajczak, Mariusz Z. [15] ; Mendez-Ferrer, Simon [4] ; Dick, John E. [5] ; Markus, Regina P. [2] ; Lapidot, Tsvee [1]
Total Authors: 32
Affiliation:
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[1] Weizmann Inst Sci, Immunol Dept, Rehovot - Israel
[2] Univ Sao Paulo, Physiol Dept, Sao Paulo - Brazil
[3] Pomeranian Med Univ, Physiol Dept, Szczecin - Poland
[4] Univ Cambridge, Haematol Dept, Cambridge - England
[5] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON - Canada
[6] Oncol Hosp, Natl Med Ctr Century XXI, IMSS, Oncol Res Unit, Mexico City, DF - Mexico
[7] Weizmann Inst Sci, Mol Cell Biol Dept, Rehovot - Israel
[8] Univ Warsaw, Regenerat Med Dept, Warsaw - Poland
[9] Weizmann Inst Sci, Life Sci Core Facil, Rehovot - Israel
[10] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin - Peoples R China
[11] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin - Peoples R China
[12] Peking Union Med Coll, Tianjin - Peoples R China
[13] Pomeranian Med Univ, Forens Med Dept, Szczecin - Poland
[14] Weizmann Inst Sci, Biol Regulat Dept, Rehovot - Israel
[15] Univ Louisville, Stem Cell Inst, Louisville, KY 40292 - USA
Total Affiliations: 15
Document type: Journal article
Source: CELL STEM CELL; v. 23, n. 4, p. 572+, OCT 4 2018.
Web of Science Citations: 14
Abstract

Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Lightinduced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/alpha SMA(+) macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation. (AU)

FAPESP's process: 15/50166-8 - Light/dark regulation of bone marrow stem cell production of blood and immune cells during homeostasis and inflammation
Grantee:Regina Pekelmann Markus
Support Opportunities: Regular Research Grants