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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients with chronic kidney disease

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Ramalho, J. [1] ; Marques, I. D. B. [1] ; Hans, Didier [2] ; Dempster, David [3, 4] ; Zhou, Hua [3] ; Patel, Parth [5] ; Pereira, R. M. R. [6] ; Jorgetti, V. [1, 7] ; Moyses, R. M. A. [1, 8] ; Nickolas, Thomas L. [9]
Total Authors: 10
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Invest Med 16, Sao Paulo, SP - Brazil
[2] Lausanne Univ Hosp, Ctr Bone Dis, Bone & Joint Dept, Lausanne - Switzerland
[3] Helen Hayes Hosp, Reg Bone Ctr, New York, NY - USA
[4] Columbia Univ, Dept Pathol & Cell Biol, New York, NY - USA
[5] Columbia Univ Coll Phys & Surg, 630 W 168th St, New York, NY 10032 - USA
[6] Univ Sao Paulo, Fac Med, Bone Lab Metab, Div Rheumatol, Sao Paulo, SP - Brazil
[7] Hosp Samaritan Amer Serv Med, Sao Paulo, SP - Brazil
[8] Univ Nove de Julho, Sao Paulo, SP - Brazil
[9] Columbia Univ, Dept Med, Med Ctr, New York, NY - USA
Total Affiliations: 9
Document type: Journal article
Source: BONE; v. 116, p. 215-220, NOV 2018.
Web of Science Citations: 5

The trabecular bone score (TBS) is a novel tool using grayscale variograms of the lumbar spine bone mineral density (BMD) to assess trabecular bone microarchitecture. Studies in patients with chronic kidney disease (CKD) suggest it may be helpful in assessing fracture risk. However, TBS has not been validated as a measure of trabecular architecture against transiliac bone biopsy with histomorphometry in CKD patients. We hypothesized that TBS would reflect trabecular architecture at the iliac crest in CKD patients. We obtained tetracycline double labeled transiliac crest bone biopsy, areal BMD of the spine, total hip, femoral neck (FN) and spine TBS by dual energy X-ray absorptiometry (DXA), and cortical and trabecular volumetric density and microarchitecture by high resolution peripheral quantitative computed tomography (HR-pQCT) in CKD patients from two centers: twenty-two patients from Columbia University Medical Center, USA and thirty patients from Hospital das Clinicas - Universidade de Sao Paulo, Brazil. Two patients were excluded for outlier status. Univariate and multivariate relationships between TBS and measures from DXA, HR-pQCT and histomorphometry were determined. Patients were 50.2 +/- 15.8 years old, 23 (46%) were men, and 33 (66%) were on dialysis. TBS was < 1.31 in 21 (42%) patients and 22%, 14% and 10% had T-scores <= -2.5 at spine, FN and total hip respectively. In univariate regression, TBS was significantly associated with trabecular bone volume (BV/TV), trabecular width (Tb.Wi), trabecular spacing, cortical width but not with trabecular number or cortical porosity. FN Z-score and height were also associated with cancellous BV/TV and Tb.Wi, In multivariate analysis, TBS remained an independent predictor of BV/TV and Tb.Wi. There were no relationships between TBS and dynamic parameters from histomorphometry. These data suggest that TBS reflected trabecular microarchitecture and cortical width measured by bone biopsy in CKD patients. Future studies should address its utility in the identification of CKD patients who may benefit from fracture prevention strategies. (AU)

FAPESP's process: 11/22962-3 - A prospective and randomized trial of zoledronic acid to prevent bone loss in the first year after kidney transplantation
Grantee:Elias David-Neto
Support type: Regular Research Grants