Cracked tooth syndrome in irradiated patients with head and neck cancer

Author(s):Show less -

Palmier, Natalia Rangel ^[1] ; Madrid, Cristhian Camilo ^{[1, 2]} ; Paglioni, Mariana de Pauli ^[1] ; Rivera, Cesar ^{[1, 3]} ; Lebre Martins, Beatriz Nascimento F. ^[1] ; Damaccno Araujo, Anna Luiza ^[1] ; Salvajoli, Joao Victor ^[4] ; de Goes, Mario Fernando ^[2] ; Lopes, Marcio Ajudarte ^[1] ; Prado Ribeiro, Ana Carolina ^{[1, 5, 6]} ; Brandao, Thais Bianca ^{[1, 5]} ; Santos-Silva, Alan Roger ^{[1, 5]}

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Restorat Dent Dept, Piracicaba Dent Sch, Campinas, SP - Brazil

^[3] Univ Talca, Dept Basic Biomed Sci, Talca - Chile

^[4] ICESP FMUSP, Inst Canc Estado Sao Paulo, Radiotherapy Serv, Sao Paulo - Brazil

^[5] ICESP FMUSP, Dent Oncol Serv, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil

^[6] Univ Brasil, Fernandopolis - Brazil

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 126, n. 4, p. 335+, OCT 2018.
• Web of Science Citations: 1

Abstract

Objectives. The aim of this study was to assess the presence of enamel craze lines (ECLs), part of the spectrum of the so-called cracked tooth syndrome, on the surface of teeth irradiated in vivo. Study Design. Forty teeth extracted from patients with head and neck cancer were paired, matched, and equally divided into 4 groups: noncarious irradiated (G1); noncarious control (G2); radiation-related caries (RRC) (G3), and carious control (G4). Samples were examined for ECL detection with a fiberoptic transillumination device and photographed, and ECL mean size, number, and patterns of topographic distribution in tooth crown were determined. Groups were compared accordingly: G1 versus G2; G3 versus G4. Results. We analyzed 538 ECLs, of which 30.1% were found in noncarious irradiated teeth, 19.3% in noncarious controls, 27.6% in RRC, and 23% in carious controls. Non-carious irradiated teeth presented higher quantities of ECL than non-carious control (P < 0.05). Higher incidences of ECLs were identified in specific enamel topographies of anterior G1 and G3 samples (P <.05). There was no correlation between ECL size/numbers and radiation isodose delivery to teeth. Conclusions. Increased incidence of ECLs may indicate weakened enamel structure in irradiated teeth, and this may play a role in the onset and progression of RRC. (AU)

• FAPESP's process: 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma
• Grantee: Ana Carolina Prado Ribeiro e Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients
• Grantee: Alan Roger dos Santos Silva
• Support Opportunities: Regular Research Grants