Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial

Author(s):Show less -

Leal Goncalves, Marcela Leticia ^[1] ; Costa da Mota, Ana Carolina ^[1] ; Deana, Alessandro Melo ^[1] ; Guedes, Guelton Hirano ^[1] ; de Souza Cavalcante, Lisyanne Araujo ^[2] ; Prates, Renato Araujo ^[1] ; Ratto Tempestini Horliana, Anna Carolina ^[1] ; Pavani, Christiane ^[1] ; Motta, Lara Jansiski ^[1] ; Bitencourt, Greice de Brito ^[3] ; Santos Fernandes, Kristianne Porta ^[1] ; Canuto Salgueiro, Monica da Consolacao ^[3] ; Mesquita-Ferrari, Raquel Agnelli ^[3] ; Teixeira da Silva, Daniela Fatima ^[1] ; Franca, Cristiane Miranda ^[4] ; Bussadori, Sandra Kalil ^[1]

Affiliation

^[1] Univ Nove de Julho, Biophoton Appl Hlth Sci, Vergueiro St 235-249, BR-01504001 Sao Paulo, SP - Brazil

^[2] Univ Nove de Julho, Vergueiro St 235-249, BR-01504001 Sao Paulo, SP - Brazil

^[3] Univ Nove de Julho, Rehabil Sci, Vergueiro St 235-249, BR-01504001 Sao Paulo, SP - Brazil

^[4] Oregon Hlth & Sci Univ, Biomat & Biomech, Sch Dent, 2730 SW Moody Ave, Portland, OR 97201 - USA

• Document type: Journal article
• Source: Trials; v. 19, OCT 29 2018.
• Web of Science Citations: 1

Abstract

BackgroundHalitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as urucum is a plant native to Brazil. The seeds are used to produce a dye that is largely used in the food, textile, paint and cosmetic industries. The aim of this study is to verify whether aPDT with Bixa orellana extract and blue light-emitting diodes (LEDs) is effective in reducing halitosis. This method will also be compared with tongue scraping, the most commonly used conventional method for tongue coating removal, and the association of both methods will be evaluated.Methods/designA randomized clinical trial will be conducted at the dental clinic of the Universidade Nove de Julho. Thirty-nine patients will be divided by block randomization into three groups (n=13) according to the treatment to be performed. In Group 1, tongue scraping will be performed by the same operator in all patients for analysis of the immediate results. Patients will also be instructed on how to use the scraper at home. Group 2 will be treated with aPDT with Bixa orellana extract and the LED light curing device: Valo Cordless Ultradent (R). Six points in the tongue dorsum with a distance of 1cm between them will be irradiated. The apparatus will be pre-calibrated at wavelength 395-480nm for 20s and 9.6J per point. In Group 3, patients will be submitted to the tongue scraping procedure, as well as to the previously explained aPDT. Oral air collection with the Oral Chroma and microbiological collections of the tongue coating shall be done before, immediately after and 7 days after treatment for comparison.DiscussionHalitosis treatment is a topic that still needs attention. The results of this trial could support decision-making by clinicians regarding aPDT using blue LEDs for treating halitosis on a daily basis, as most dentists already have this light source in their offices.Trial registrationClinicalTrials.gov, NCT03346460. Registered on 17 November 2017. (AU)

• FAPESP's process: 17/19983-5 - ACTION OF RED LED PHOTODYNAMIC THERAPYIN MICROORGANISM RELATED TO HALITOSE: CONTROLLED AND RANDOMIZED CLINICAL TRIAL.
• Grantee: Sandra Kalil Bussadori
• Support Opportunities: Regular Research Grants