The impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes

Author(s)

Murbach Teles Andrade, Bruna Fernanda ^[1] ; Barbosa, Lidiane Nunes ^[2] ; Bergamo Alves, Fernanda Cristina ^[1] ; Pereira Marques, Ana Flavia ^[1] ; Albano, Mariana ^[1] ; Mores Rall, Vera Lucia ^[1] ; Brueggemann, Holger ^[3] ; Fernandes Junior, Ary ^[1]

Affiliation

^[1] UNESP, Inst Biosci Botucatu, Dept Microbiol & Immunol, Campus Botucatu, Rua Dr Plinio Pinto e Silva S-N, BR-18618691 Botucatu, SP - Brazil

^[2] Univ Paranaense UNOPAR, Umuarama - Brazil

^[3] Aarhus Univ, Dept Biomed, Aarhus C - Denmark

• Document type: Journal article
• Source: Journal of Pharmacy and Pharmacology; v. 70, n. 12, p. 1688-1699, DEC 2018.
• Web of Science Citations: 1

Abstract

Objectives The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. martini EO and its major compound, geraniol, on C. acnes. Methods Key findings The minimum inhibitory concentration against C. acnes strains, phenotypic changes and responses of the proteome was determined. In addition, was assessed the effect of compounds in RNA-binding assay, on C. acnes-exposed keratinocytes and on the C. acnes type distribution on shoulder skin. The range of the MIC was 0.7 to 1.6 mg/ml for the three main C. acnes types. There were no cytotoxic effects of compounds in the absence or presence of C. acnes; after 7 days of exposure to C. martini EO, we could not detect a major shift of the C. acnes types on shoulder skin that was found to be dominated by C. acnes strains of types II and IA2. Conclusions Our work gives novel insight into the skin microbiota-interacting properties of C. martini EO. (AU)

• FAPESP's process: 15/12906-0 - The impact of Cymbopogon martinii-derived essential oils on the human skin microbiota and its interaction with the dermis and epidermis
• Grantee: Bruna Fernanda Murbach Teles Andrade
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 14/24094-7 - The impact of Cymbopogon martinii essential oil on the human skin microbiota and its interaction with the dermis and epidermis
• Grantee: Bruna Fernanda Murbach Teles Andrade
• Support Opportunities: Scholarships in Brazil - Post-Doctoral