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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

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Kiyuna, Ligia Akemi [1] ; Prestes e Albuquerque, Ruda [1] ; Chen, Che-Hong [2] ; Mochly-Rosen, Daria [2] ; Batista Ferreira, Julio Cesar [1]
Total Authors: 5
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Ave Prof Lineu Prestes 2415, BR-05508000 Sao Paulo, SP - Brazil
[2] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 - USA
Total Affiliations: 2
Document type: Review article
Source: Free Radical Biology and Medicine; v. 129, p. 155-168, DEC 2018.
Web of Science Citations: 14

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and aldehydic load is a hallmark of heart failure. Recently, different research groups have provided evidence that selective activation of mitochondrial detoxifying systems that counteract excessive accumulation of ROS, RNS and reactive aldehydes is sufficient to stop cardiac degeneration upon chronic stress, such as heart failure. Therefore, pharmacological and non-pharmacological approaches targeting mitochondria detoxification may play a critical role in the prevention or treatment of heart failure. In this review we discuss the most recent findings on the central role of mitochondrial dysfunction, oxidative stress and aldehydic load in heart failure, highlighting the most recent preclinical and clinical studies using mitochondria-targeted molecules and exercise training as effective tools against heart failure. (AU)

FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/16694-2 - Impact of 4-hydroxinonenal on DICER regulation: a translational approach
Grantee:Julio Cesar Batista Ferreira
Support type: Regular Research Grants
FAPESP's process: 17/14426-0 - Oxidative stress-mediated post-translational regulation of Dicer: structural and functional characterization of 4-HNE-DICER interaction
Grantee:Ligia Akemi Kiyuna
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 12/05765-2 - Contribution of aldehyde dehydrogenase 2 to heart failure development
Grantee:Julio Cesar Batista Ferreira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/00900-0 - Impact of aldehydes on dicer activity and expression profile: benefits of ALDH2 activation
Grantee:Ligia Akemi Kiyuna
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/20783-5 - Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor
Grantee:Julio Cesar Batista Ferreira
Support type: Regular Research Grants