Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities

Author(s)

Kiyuna, Ligia Akemi ^[1] ; Prestes e Albuquerque, Ruda ^[1] ; Chen, Che-Hong ^[2] ; Mochly-Rosen, Daria ^[2] ; Batista Ferreira, Julio Cesar ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Ave Prof Lineu Prestes 2415, BR-05508000 Sao Paulo, SP - Brazil

^[2] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 - USA

• Document type: Review article
• Source: Free Radical Biology and Medicine; v. 129, p. 155-168, DEC 2018.
• Web of Science Citations: 14

Abstract

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and aldehydic load is a hallmark of heart failure. Recently, different research groups have provided evidence that selective activation of mitochondrial detoxifying systems that counteract excessive accumulation of ROS, RNS and reactive aldehydes is sufficient to stop cardiac degeneration upon chronic stress, such as heart failure. Therefore, pharmacological and non-pharmacological approaches targeting mitochondria detoxification may play a critical role in the prevention or treatment of heart failure. In this review we discuss the most recent findings on the central role of mitochondrial dysfunction, oxidative stress and aldehydic load in heart failure, highlighting the most recent preclinical and clinical studies using mitochondria-targeted molecules and exercise training as effective tools against heart failure. (AU)

• FAPESP's process: 17/16694-2 - Impact of 4-hydroxinonenal on DICER regulation: a translational approach
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/14426-0 - Oxidative stress-mediated post-translational regulation of Dicer: structural and functional characterization of 4-HNE-DICER interaction
• Grantee: Ligia Akemi Kiyuna
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 16/00900-0 - Impact of aldehydes on dicer activity and expression profile: benefits of ALDH2 activation
• Grantee: Ligia Akemi Kiyuna
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
• Grantee: Carlos Eduardo Negrão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/20783-5 - Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/05765-2 - Contribution of aldehyde dehydrogenase 2 to heart failure development
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC