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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Purinergic plasticity within petrosal neurons in hypertension

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Moraes, Davi J. A. [1] ; da Silva, Melina P. [1] ; Spiller, Pedro F. [1] ; Machado, Benedito H. [1] ; Paton, Julian F. R. [2]
Total Authors: 5
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, Cardiovasc Auton Res Cluster, Auckland - New Zealand
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 1

The carotid bodies are peripheral chemoreceptors and contribute to the homeostatic maintenance of arterial levels of O-2, CO2, and {[}H+]. They have attracted much clinical interest recently because of the realization that aberrant signaling in these organs is associated with several pathologies including hypertension. Herein, we describe data suggesting that sympathetic overactivity in neurogenic hypertension is, at least in part, dependent on carotid body tonicity and hyperreflexia that is related to changes in the electrophysiological properties of chemoreceptive petrosal neurons. We present results showing critical roles for both ATP levels in the carotid bodies and expression of P2X3 receptors in petrosal chemoreceptive, but not baroreceptive, terminals in the etiology of carotid body tonicity and hyperreflexia. We discuss mechanisms that may underlie the changes in electrophysiological properties and P2X3 receptor expression in chemoreceptive petrosal neurons, as well as factors affecting ATP release by cells within the carotid bodies. Our findings support the notion of targeting the carotid bodies to reduce sympathetic outflow and arterial pressure, emphasizing the potential clinical importance of modulating purinergic transmission to treat pathologies associated with carotid body dysfunction but, importantly, sparing physiological chemoreflex function. (AU)

FAPESP's process: 16/24869-4 - Participation of lactate and carotid bodies in the respiratory responses of rats submitted to anaerobic physical exercise
Grantee:Pedro Favoretto Spiller
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/10484-5 - Electrophysiological and molecular characterization of neurons involved in the generation of respiratory rhythm and pattern of rats during postnatal development
Grantee:Davi José de Almeida Moraes
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/01073-7 - Electrophysiological characterization of expiratory motoneurons in rats submitted to sustained hypoxia
Grantee:Melina Pires da Silva Moraes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
Grantee:Benedito Honorio Machado
Support type: Research Projects - Thematic Grants