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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice

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Author(s):
M.M. Antunes [1] ; C.B. de Almeida-Souza [2] ; G. Godoy [3] ; A.R. Crisma [4] ; L.N. Masi [5] ; R. Curi [6] ; R.B. Bazotte [7]
Total Authors: 7
Affiliation:
[1] Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica - Brasil
[2] Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica - Brasil
[3] Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica - Brasil
[4] Universidade Federal do Paraná. Departamento de Análises Clínicas - Brasil
[5] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[6] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[7] Universidade Estadual de Maringá. Departamento de Farmacologia e Terapêutica - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 52, n. 1 2018-12-10.
Abstract

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes. (AU)

FAPESP's process: 16/15766-7 - Hypertrophy Skeletal muscle in STZ diabetic rats.
Grantee:Rui Curi
Support Opportunities: Regular Research Grants