General Protocol to Obtain D-Glucosamine from Biomass Residues: Shrimp Shells, Cicada Sloughs and Cockroaches

Author(s)

Bertuzzi, Diego L. ^[1] ; Becher, Tiago B. ^[1] ; Capreti, Naylil M. R. ^[1] ; Amorim, Julio ^[1] ; Jurberg, Igor D. ^[1] ; Megiatto, Jr., Jackson D. ^[1] ; Ornelas, Catia ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: GLOBAL CHALLENGES; v. 2, n. 11 NOV 2018.
• Web of Science Citations: 0

Abstract

A general protocol is developed to obtain D-glucosamine from three widely available biomass residues: shrimp shells, cicada sloughs, and cockroaches. The protocol includes three steps: (1) demineralization, (2) deproteinization, and (3) chitin hydrolysis. This simple, general protocol opens the door to obtain an invaluable nitrogen-containing compound from three biomass residues, and it can potentially be applied to other chitin sources. White needle-like crystals of pure D-glucosamine are obtained in all cases upon purification by crystallization. Characterization data (NMR, IR, and mass spectrometry) of D-glucosamine obtained from the three chitin sources are similar and confirm its high purity. NMR investigation demonstrates that D-glucosamine is obtained mainly as the alpha-anomer, which undergoes mutarotation in aqueous solution achieving equilibrium after 440 min, in which the anomeric glucosamine distribution is 60% alpha-anomer and 40% beta-anomer. (AU)

• FAPESP's process: 18/02093-0 - Development of new nanomaterials for nanomedicine applications
• Grantee: Cátia Cristina Capêlo Ornelas Megiatto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/04929-0 - Development of biosensors for instantaneous detection of proteins and cancer cells, for application on on-site biopsy
• Grantee: Diego Luan Bertuzzi
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/24017-0 - Application of Isoxazolones in Organic Synthesis
• Grantee: Igor Dias Jurberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/15718-7 - Exploring 5-isoxazolones for the synthesis of beta-aminoacids
• Grantee: Naylil Malagutti Rodrigues Capreti
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/22160-0 - Development of original synthetic strategies for the preparation of supramolecular Interlocked polymers
• Grantee: Jackson Dirceu Megiatto Junior
• Support Opportunities: Research Grants - Young Investigators Grants