Profile of high-fluoride toothpastes combined or not with functionalized tri-calcium phosphate on root dentin caries control: An in vitro study

Author(s)

de Amoedo Campos Velo, Marilia Mattar ^[1] ; Magalhaes, Ana Carolina ^[2] ; Shiota, Aymee ^[3] ; Herrera Farha, Ana Laura ^[3] ; Grizzo, Larissa Tercilia ^[3] ; Honorio, Heitor Marques ^[4] ; Wang, Linda ^[5]

Affiliation

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Operat Dent Endodont & Dent Mat, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Biol Sci, Bauru, SP - Brazil

^[3] Univ Sao Paulo, Dept Biol Sci, Biochem Lab, Bauru, SP - Brazil

^[4] Univ Sao Paulo, Dept Pediat Dent Orthodont & Collect Hlth, Bauru, SP - Brazil

^[5] Univ Sao Paulo, Dept Operat Dent Endodont & Dent Mat, Bauru, SP - Brazil

• Document type: Journal article
• Source: AMERICAN JOURNAL OF DENTISTRY; v. 31, n. 6, p. 290-296, DEC 2018.
• Web of Science Citations: 2

Abstract

Purpose: This in vitro study was conducted in two regimens hypothesizing that high-fluoride (F) toothpaste (5,000 mu g F/g) with or without functionalized tri-calcium phosphate (f TCP) would provide additional protection against (1) root caries development and (2) progression. For both regimens, bovine root dentin specimens were used. Methods: In regimen 1, 60 specimens were subjected daily to alternate immersions between demineralizing and remineralizing solutions for 7 days. The specimens were randomly distributed into four treatment groups (n=15): non-F toothpaste; Colgate Total 12 (CT) (1,450 mu g F/g); Colgate Prevident (CP) (5,000 mu g F/g); and Clinpro 5000 (CL) (5,000 mu g F/g) associated with (f TCP), and treated with toothpastes/water slurries (1: 3 w/w) (5 minutes), twice a day. In regimen 2, the efficacy of the toothpastes to inhibit the progression of the developed lesions was assessed, using the previously described pH-cycling model without additional treatment. The response variables were based on the percentage of surface hardness change (ASH), cross-sectional hardness (Delta CSH), mineral content/lesion depth by transversal microradiography (TMR) and the alkali-soluble F uptake. Results: Both high-F toothpastes reduced initial dentin demineralization and increased the F uptake compared to non-F and conventional toothpastes (P< 0.05). In terms of caries lesion progression, all tested toothpastes were able to promote this protection. (AU)

• FAPESP's process: 15/00817-2 - In vitro and In situ evaluation of the effect of high-fluoride and arginine-based toothpastes on the control of root caries
• Grantee: Marilia Mattar de Amoêdo Campos Velo
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/53849-8 - Acquisition of a system of transverse microradiography for studies on tooth demineralization and remineralization, associated or not to adhesive restorations
• Grantee: Ana Carolina Magalhães
• Support Opportunities: Multi-user Equipment Program