| Full text | |
| Author(s): |
Barboza, Renato
[1]
;
Hasenkamp, Lutero
[2]
;
Barateiro, Andre
[2]
;
Murillo, Oscar
[2]
;
Machado Peixoto, Erika Paula
[2]
;
Lima, Flavia Afonso
[2]
;
Reis, Aramys Silva
[2]
;
Goncalves, Ligia Antunes
[2]
;
Epiphanio, Sabrina
[3]
;
Marinho, Claudio R. F.
[2]
Total Authors: 10
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | FRONTIERS IN MICROBIOLOGY; v. 10, JAN 29 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Placental malaria (PM) remains a severe public health problem In areas of high malaria transmission. Despite the efforts to prevent Infection poor outcomes in Plasmodium endemic areas, there is still a considerable number of preterm births and newborns with low birth weight resulting from PM. Although local Inflammation triggered In response to malaria is considered crucial In Inducing placental damage, little Is known about the differential Influence of maternal and fetal Immune responses to the disease progression. Therefore, using a PM mouse model, we sought to determine the contribution of maternal and fetal innate immune responses to PM development. For this, we conducted a series of cross-breeding experiments between mice that had differential expression of the MyD88 adaptor protein to obtain mother and correspondent fetuses with distinct genetic backgrounds. By evaluating fetal weight and placental vascular spaces, we have shown that the expression of MyD88 In fetal tissue has a significant impact on PM outcomes. Our results highlighted the existence of a distinct contribution of maternal and fetal immune responses to PM onset. Thus, contributing to the understanding of how inflammatory processes lead to the dysregulatlon of placental homeostasis ultimately impairing fetal development. (AU) | |
| FAPESP's process: | 11/17880-8 - Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms |
| Grantee: | Renato Barboza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/10892-1 - Study of the inflammatory mechanisms mediated by innate immunity receptors in Amyotrophic Lateral Sclerosis |
| Grantee: | Renato Barboza |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/53256-7 - Distress syndrome in a murine model associated to the severe malaria: a study of parasite-host interaction |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 12/14715-9 - Role of the adaptor protein MyD88 on the placental Malaria |
| Grantee: | Lutero Augusto Hasenkamp |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/07030-0 - Characterization of autophagic activity and inflammasome in placental malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 17/03939-7 - Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria |
| Grantee: | André Filipe Rivais Martins Barateiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/19048-8 - Role of Inflamassoma in the immunopathogenesis of Placental Malaria |
| Grantee: | Aramys Silva dos Reis |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/16417-8 - Autophagy in placental malaria: effects and mechanisms |
| Grantee: | Flávia Afonso Lima |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Young Investigators Grants |