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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Collagen-supported CaCO3 cylindrical particles enhance Ti bioactivity

Full text
Author(s):
Tovani, C. B. [1] ; Faria, A. N. [1, 2] ; Ciancaglini, P. [1] ; Ramos, A. P. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SURFACE & COATINGS TECHNOLOGY; v. 358, p. 858-864, JAN 25 2019.
Web of Science Citations: 1
Abstract

Even though Ti displays outstanding properties as a bone-substituting material, its low osseointegration rate has motivated several studies to improve its surface features and thus overcome this limitation. In this sense, physical and chemical modifications by immobilization of bioactive cues are a promising tool to enhance Ti biological responses. Here, we used the layer-by-layer (LbL) technique to modify Ti surface with collagen (Col), the most abundant protein in the bone extracellular matrix, associated with a hierarchical topography through immobilization of CaCO3 particles with controlled size and morphology. Infrared spectroscopy and scanning electron microscopy revealed that Col and CaCO3 particles were immobilized on Ti, to form a homogeneous film. Contact angle measurements demonstrated that Ti surface modification increased the total surface free energy and its polar component, to alter Ti wettability. Ti roughness also increased after film formation as evidenced by confocal microscopy images. Exposure to simulated body fluid and osteoblast culture attested that the films were bioactive and suitable for cell proliferation. In summary, the approach described herein modifies Ti surface properties such as roughness, charge, and chemical composition, to enhance the biological response of Ti implants. (AU)

FAPESP's process: 13/12615-0 - Obtainment and characterization of calcium carbonate nanotubes aiming the preparation of bioactive surfaces
Grantee:Camila Bussola Tovani
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/08892-9 - Bioactive surfaces designed from Langmuir-Blodgett Films and Biominerals
Grantee:Ana Paula Ramos
Support Opportunities: Regular Research Grants
FAPESP's process: 14/24249-0 - Association of osteogenic proteins in biominerals and metallic oxides doped with rare-earth: interaction with membrane models systems
Grantee:Camila Bussola Tovani
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/21236-0 - Extracellular matrix vesicles (MVs) mimetic systems to study the regulation of the biomineralization process: proteoliposomes containing NPP1 and Annexin V
Grantee:Pietro Ciancaglini
Support Opportunities: Regular Research Grants
FAPESP's process: 12/20946-3 - Study of the growth of calcium phosphates and carbonates on organic matrices deposited on mettalic supports: obtainment of osteoinductive biomaterials
Grantee:Ana Paula Ramos
Support Opportunities: Regular Research Grants