| Full text | |
| Author(s): |
M.G. Loureiro
[1]
;
C.A. Rodrigues
[2]
;
E.S. Nascimento
[3]
;
C. Esteban
[4]
;
S.H. Perri
[5]
;
C.R. Anhesini
[6]
Total Authors: 6
|
| Affiliation: | [1] UNIP. Curso de Medicina Veterinária
[2] UNIP. FO. Curso de Medicina Veterinária
[3] USP. Faculdade de Ciências Farmacêuticas
[4] Santa Casa. Faculdade de Ciências Médicas
[5] UNIP. FO. Curso de Medicina Veterinária
[6] UNESP. Faculdade de Medicina Veterinária e Zootecnia
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 62, n. 1, p. 13-22, 2010-02-00. |
| Abstract | |
The efficacy of topical versus systemic treatment with oxytetracycline for papillomatous digital dermatitis (PDD) in dairy cows was compared. Antimicrobial residues in milk and their concentrations in synovial fluid and plasma were analysed. Sixteen lactating Holstein cows with PDD lesions were topically treated with oxytetracycline powder (group 1) or long-acting oxytetracycline (group 2). Plasma, synovial fluid, and milk samples were collected in the following moments: M0 (before treatments); at six hours after treatments (M1), and at 12-hour intervals until 264 hours after treatments (M23). Lameness score and lesion size were evaluated. Analysis of oxytetracycline concentration was performed by high-performance liquid chromatography (HPLC). Cows in group 1 showed reduced lesion size and lameness score when compared to cows in group 2. None of the plasma, synovial fluid, or milk samples collected from cows in group 1 were positive to oxytetracycline. However, violative antimicrobial residues were detected in milk samples collected from cows in group 2, from M1 until M23. Topical application of oxytetracycline powder was an efficient treatment for PDD with no risk of violative antimicrobial residues in milk or increases its concentration in plasma or synovial fluid. The systemic administration of oxytetracycline was inefficient to treat PDD and caused violative residues in milk. (AU) | |
| FAPESP's process: | 05/02462-5 - Comparison of tetracycline concentration in plasma, synovial fluid and milk from papillomatous digital dermatites dairy cattle submitted to injectable long action and powder associated to bandages in multiple-dose |
| Grantee: | Celso Antonio Rodrigues |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 08/02715-9 - Clinic evaluation of oxytetracycline long action and concentration in milk, synovial fluid and plasma from dairy cattle with popillomatous digital dermatitis submitted to multipledosing. |
| Grantee: | Celso Antonio Rodrigues |
| Support Opportunities: | Research Grants - Meeting - Abroad |