Genotoxicity of textile dye CI Disperse Blue 291 in mouse bone marrow

Author(s)

Fernandes, Fabio Henrique ^[1] ; Umbuzeiro, Gisela de Aragao ^[2] ; Favero Salvadori, Daisy Maria ^[3]

Affiliation

^[1] UNESP Sao Paulo State Univ, Med Sch, Dept Pathol Rubido Jr, BR-18618687 Botucatu, SP - Brazil

^[2] UNICAMP Univ Canipinas, Technol Sch, Paschoal Marmo 1888, Limeira, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Med Sch, Dept Pathol Rubiao Jr, BR-18618687 Botucatu, SP - Brazil

• Document type: Journal article
• Source: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS; v. 837, p. 48-51, JAN 2019.
• Web of Science Citations: 1

Abstract

Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yam dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed. (AU)

• FAPESP's process: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
• Grantee: Maria Valnice Boldrin
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 08/10449-7 - Assessment of occurrence, toxicity/genotoxicity and degradation processes of dyes in effluents and surface water
• Grantee: Maria Valnice Boldrin
• Support type: Research Projects - Thematic Grants