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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Solid lipid nanoparticles stabilized by sodium caseinate and lactoferrin

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Author(s):
Bernardes Oliveira, Davi Rocha [1] ; Furtado, Guilherme de Figueiredo [1] ; Cunha, Rosiane Lopes [1]
Total Authors: 3
Affiliation:
[1] Univ Campinas UNICAMP, Fac Food Engn, Dept Food Engn, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: FOOD HYDROCOLLOIDS; v. 90, p. 321-329, MAY 2019.
Web of Science Citations: 2
Abstract

Tristearin solid lipid nanoparticles were produced by the solvent displacement technique using native and dissociated sodium caseinate or lactoferrin as natural surfactants in different concentrations. All particles showed nanometric size and monomodal distribution, but the dissociated sodium caseinate were able to produce particles with a slight smaller size and polydispersity. Differential scanning calorimetry analysis showed that nanoparticles stabilized with proteins might present multiple crystalline form, which could be very attractive for hydrophobic bioactive incorporation. In fact, beta-carotene loaded nanoparticles stabilized with dissociated sodium caseinate showed a better protection against bioactive degradation, which was associated to the more efficient coverage of lipid surface, since protein molecules were previously unfolded. Lactoferrin covering tristearin nanoparticles also presented good results regarding beta-carotene protection. Protein covering solid lipid nanoparticles are novelty among nanocarrier systems and exhibit some advantages such as reduced particle size, elevated surface charge, good protection for hydrophobic compounds and substitution of synthetic emulsifiers by natural ones, which makes this a potential and versatile delivery system for food and pharmaceutical applications. (AU)

FAPESP's process: 06/03263-9 - Process, packaging, edible coatings application and final quality evaluation of some high moisture tropical fruits
Grantee:Miriam Dupas Hubinger
Support Opportunities: Regular Research Grants
FAPESP's process: 09/54137-1 - Acquisition of a particle size/distribution analyzer, a zeta potential measurement system, a spray dryer, and an ultra-high-pressure liquid chromatograph/mass spectrometer
Grantee:Miriam Dupas Hubinger
Support Opportunities: Multi-user Equipment Program